ID A0A225B6Q0_9EURO Unreviewed; 715 AA.
AC A0A225B6Q0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OKL63809.1};
GN ORFNames=UA08_00418 {ECO:0000313|EMBL:OKL63809.1};
OS Talaromyces atroroseus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Trachyspermi.
OX NCBI_TaxID=1441469 {ECO:0000313|EMBL:OKL63809.1, ECO:0000313|Proteomes:UP000214365};
RN [1] {ECO:0000313|EMBL:OKL63809.1, ECO:0000313|Proteomes:UP000214365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 11181 {ECO:0000313|EMBL:OKL63809.1,
RC ECO:0000313|Proteomes:UP000214365};
RA Rasmussen K.B., Rasmussen S., Petersen B., Sicheritz-Ponten T.,
RA Mortensen U.H., Thrane U.;
RT "Talaromyces atroroseus IBT 11181 draft genome.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKL63809.1}.
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DR EMBL; LFMY01000001; OKL63809.1; -; Genomic_DNA.
DR RefSeq; XP_020123930.1; XM_020260222.1.
DR AlphaFoldDB; A0A225B6Q0; -.
DR STRING; 1441469.A0A225B6Q0; -.
DR GeneID; 31000173; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000214365; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000214365}.
FT REGION 335..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 79166 MW; 4A2F99CCEB7EAF4F CRC64;
MEKITEKIAA LPPDERYFSL EFFPPKTQMG SVNLQARLER MAQALRPLFV TVTWGAGGTT
AAKSLELAEI CQRQLQLTTC LHLTCTNMNR KLIDEALEEA KALGIRNILA LRGDPPRSEE
YNMDGDDDSN KDFTWAIDLV RYIRRTHGDY FCLGVAAYPE GHPGESQTDI QDPEKDLPYL
VDKVQAGADF IMTQLTYDFD AYKKFEESVR NHPSGAMKNI PIIPGLMPIH GYKILTRVTK
LSGAHIPPAI MSRLEQVKTD DEQVKQVGVD IVSEIVDQIK ELPRSGHRGY HFYTLNLEKS
VSFILERCDL IPQFSQDSAV DEDIAVEDAA SSNNIDGVKP TALSRRRASS INSGPHNRVI
VDKLHVPTDQ QSERSSKRSI TYETLASSAG VPALNPPPRS TQLQISEGVG SLGREATWDD
FPNGRWGDSR SPAFGEIDGY GPSLHVNATT ARQLWGFPVT RDDIGALFRK HVAGELYIVP
WSEGGAAEDA NLNAETQVIK SQLLQIIEKK NWWTLASQPA VNGVRSDDPI FGWGPPGEGF
VFQKAFVEFF CPSSDYQTKV KPTLLKHGSE EFAWFATNAA GDFESSFSAV AASSSSSPPS
SSPGASAADD EQVEISENTG MAVTWGAFRG REITTPTIIE GVSFHAWGEE AFRIWDEWRR
IYPRGSATER LLNETKNDVW LVCVIGHRYG AGNEPGSEAE KKEMNMLWDV LAGDM
//
