ID   A0A225D6T8_9BACT        Unreviewed;       850 AA.
AC   A0A225D6T8;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=CRISPR-associated helicase Cas3 {ECO:0000313|EMBL:OWK37310.1};
GN   ORFNames=FRUB_06430 {ECO:0000313|EMBL:OWK37310.1};
OS   Fimbriiglobus ruber.
OC   Bacteria; Planctomycetota; Planctomycetia; Gemmatales; Gemmataceae;
OC   Fimbriiglobus.
OX   NCBI_TaxID=1908690 {ECO:0000313|EMBL:OWK37310.1, ECO:0000313|Proteomes:UP000214646};
RN   [1] {ECO:0000313|Proteomes:UP000214646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP5 {ECO:0000313|Proteomes:UP000214646};
RA   Ravin N.V., Rakitin A.L., Ivanova A.A., Beletsky A.V., Kulichevskaya I.S.,
RA   Mardanov A.V., Dedysh S.N.;
RT   "Genome analysis of Fimbriiglobus ruber SP5, the first member of the order
RT   Planctomycetales with confirmed chitinolytic capability.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC       nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC   -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC       helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWK37310.1}.
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DR   EMBL; NIDE01000014; OWK37310.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A225D6T8; -.
DR   OrthoDB; 9810236at2; -.
DR   Proteomes; UP000214646; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3210.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR   InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR013444; Helicase_Cas3_CRISPR-ass_Anaes.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR02621; cas3_GSU0051; 1.
DR   PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR   PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR   Pfam; PF18019; Cas3_HD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51643; HD_CAS3; 1.
PE   3: Inferred from homology;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000214646}.
FT   DOMAIN          664..837
FT                   /note="HD Cas3-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51643"
SQ   SEQUENCE   850 AA;  94910 MW;  B55105856D1AF407 CRC64;
     MSPQQLDFEE TFKLLTGNGP FPWQTALYNR FVADRRDNIP ASCNLPTGLG KTSVIAVWLI
     ALAHGANVPR RLVYVVNRRT VVDQTTDEVE KYRERLNGLA DPSPLKDKLG SLALSTLRGQ
     FADNRKWSED PSRPAVICGT VDMIGSRLLF SGYGIGFKQK PLHAGFLGQD ALLVHDEAHL
     EPAFQSLITA IEKEQNRCGD FRPVRVMELT ATSRGGSDAF GLTDEDMVDS TVRQRVTAQK
     TLHLHESTDK KKLAEQISEL ALRFKDSGRA VLVFVRTVED VMKVRDKLPK GTVETLTGTM
     RGKERDELVG NQTFARFLPN AASGEKTVYL VCTSAGEVGV NISADHLVCD LSTFDSMAQR
     FGRVNRFGEH NFTEIHVVHP AEFEDDEYDQ RCGKTLNLLR RLNGSASPAS LGELPATERQ
     AAFAPPPTIL PVTDILFDAW ALTTIRDKLP GRPKVEPFLH GLSDWEPPET HVAWREEVER
     LQPKYQDAEE DKEREGEDRK AIAKQAGELL DAYPLKPHEL LREPSYRAFK HFEAMAKRCP
     NAPVWLLDDD GNVQVLTVGE LADKDDKKRI EGMTVLLPPT AGGLESGMLN GSTPAPQPAD
     LDVADKYFAP DGHKQLRVRV WDEEDKLASG MRLVREVSLP TNGDDEVEPK VWFWFSRENE
     GEKSAPKPVE WSVHVDDVVT RTRAIVANLP LPEEIKKAIV VAAQCHDHGK RRKLFQTVLG
     NFRFPTLVLA KSGAKSGGKV IEKYRHEFGS LLDSRDEKDF QELADELKEL VLHVIASHHG
     RARPHFPSEE VFDPDCSDTA AGTVAACVPR RFARLQRKYG RWGLAYLESL LRAADWAAST
     SPSKYLGDEK
//