ID A0A225MN94_9BURK Unreviewed; 495 AA.
AC A0A225MN94;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Exopolyphosphatase {ECO:0000256|ARBA:ARBA00020416};
DE EC=3.6.1.11 {ECO:0000256|ARBA:ARBA00012451};
GN Name=ppx {ECO:0000313|EMBL:OWT60249.1};
GN ORFNames=CEY11_11365 {ECO:0000313|EMBL:OWT60249.1};
OS Candidimonas nitroreducens.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Candidimonas.
OX NCBI_TaxID=683354 {ECO:0000313|EMBL:OWT60249.1, ECO:0000313|Proteomes:UP000214603};
RN [1] {ECO:0000313|Proteomes:UP000214603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC-089 {ECO:0000313|Proteomes:UP000214603};
RA Fan M., Lin Y.;
RT "Herbaspirillum phytohormonus sp. nov., isolated from the root nodule of
RT Robinia pseudoacacia in lead-zinc mine.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate;
CC Xref=Rhea:RHEA:21528, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14279,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16838,
CC ChEBI:CHEBI:43474; EC=3.6.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000209};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GppA/Ppx family.
CC {ECO:0000256|ARBA:ARBA00007125}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWT60249.1}.
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DR EMBL; NJIH01000006; OWT60249.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225MN94; -.
DR OrthoDB; 9793035at2; -.
DR Proteomes; UP000214603; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004309; F:exopolyphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006793; P:phosphorus metabolic process; IEA:InterPro.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR022371; Exopolyphosphatase.
DR InterPro; IPR048950; Ppx_GppA_C.
DR InterPro; IPR003695; Ppx_GppA_N.
DR InterPro; IPR030673; PyroPPase_GppA_Ppx.
DR NCBIfam; TIGR03706; exo_poly_only; 1.
DR PANTHER; PTHR30005; EXOPOLYPHOSPHATASE; 1.
DR PANTHER; PTHR30005:SF14; EXOPOLYPHOSPHATASE; 1.
DR Pfam; PF02541; Ppx-GppA; 1.
DR Pfam; PF21447; Ppx-GppA_III; 1.
DR PIRSF; PIRSF001267; Pyrophosphatase_GppA_Ppx; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000214603}.
FT DOMAIN 23..304
FT /note="Ppx/GppA phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02541"
FT DOMAIN 312..479
FT /note="Ppx/GppA phosphatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21447"
SQ SEQUENCE 495 AA; 54645 MW; 4AB36A07BAE1F6D0 CRC64;
MDQLLAAVDL GSNSFRLSIG RVVQHEGSAQ IYAVDRLKES VRLAAGLGSD KMLDQDAMDR
AVAVLKRFGE RIAGFHPNRV RAVATNTFRV ARNAAQLLPR AEAALGFPIE VISGQEEARL
IFSGVANELP PSPNKRLVID IGGGSTEVII GRGYEPLRMA SLYLGCVSYA QAYFPDGRVT
AARMEQAQLA ARREFETISW PYRKTGWQEA YGSSGTAKGL YAVLTEGGMS SKGITQQGLE
KLRAKLIRDG RVLIDELPGL KPDRAPVLAA GLAIMLAAFD ELHIKLMRTG DGALRMGVLY
DLLGRDSDQD KREQTVHQFI KRYHIDMLQA NRVRGLALHF FEQLDLPEDE RPDLARALEW
AAELHETGLS IAHADYHKHS AYILGHADMP GFSNDGQALL AWLALGHQGK LNKLRAHEST
RAQWLTLLCL RLAVLLSRRR VDLEKPPLAI AADARCIHIR VNGSWLAEHP LSAYTLRGEV
AQWNKAGFEM ALQEA
//
