ID A0A225V3B7_9STRA Unreviewed; 698 AA.
AC A0A225V3B7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:OWY99437.1};
GN ORFNames=PHMEG_00029558 {ECO:0000313|EMBL:OWY99437.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWY99437.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWY99437.1}.
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DR EMBL; NBNE01008487; OWY99437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225V3B7; -.
DR EnsemblProtists; OWY99437; OWY99437; PHMEG_00029558.
DR OrthoDB; 1123912at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09279; RNase_HI_like; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF36; RT_RNASEH_2 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000313|EMBL:OWY99437.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:OWY99437.1};
KW Transferase {ECO:0000313|EMBL:OWY99437.1}.
FT DOMAIN 122..329
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 78051 MW; A8357116D2F62882 CRC64;
MPDQATDRTG TKDIKTEDRT GIKDIEPKAE NQTQIRLDQG QIKLDPDAIP PICHTESVEQ
RDPPTKGPAA TNSQDAEDEV EIYYHDSGDL SPEDLEGNLA VLPEIPISTT AKVSIEDLQG
LLAAEIIRPS TPPWASPIVI VRKSNGVDIR LCIDYKMVNS LTRLMVYPMP LISDLLEDLD
KALWYCSLDM ASGFWVVPMT DRAREISAFI TPFGLFEWSR MPFGLKNAPQ IYQRLVDNAL
YGFLEISRSG DAGATTDVFQ TGIVDDPDRE SVLGRRSYID EIMIAAESWD QMCRRAEDLL
EACDKWNLSI SVAKSFWGMD KVGYLGHRVS IGGLEASPME ASPKDLKSLT DLPFPGSLRS
MQSFLGSLNY YSRIIEYYAI YASVLYELRE MEFTELEKRS DLREILDRND PIPRDHDPTE
LNGREAHRAF TALKTKIATT PVLRHFDETR TPGRLGQWSA LLAPWTLEIT KCSKGEDEIL
GAIAASITPR AKIDDALTEI APRKEAKRRI QTAIVWSLPG WEVVKARSGY LESLTVNEAE
YNGLILGLDM IDGLVRRRLV ICGDSNLVVR QVRGEIDCKA PELTLLKRKA LGRLRKWNDH
ELVHVKRDWN GSADSLASAA LQRQRGIEVQ ATPGYQELVT LNRLDAILIP KTENPVVRVA
AVTTRAGRAR SPAGVMDEGL IREILVDRIK RKKSGSLA
//
