ID A0A225V6H6_9STRA Unreviewed; 475 AA.
AC A0A225V6H6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Phosphatidylinositol kinase {ECO:0000313|EMBL:OWZ01051.1};
DE Flags: Fragment;
GN ORFNames=PHMEG_00027637 {ECO:0000313|EMBL:OWZ01051.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ01051.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ01051.1}.
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DR EMBL; NBNE01007138; OWZ01051.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225V6H6; -.
DR STRING; 4795.A0A225V6H6; -.
DR EnsemblProtists; OWZ01051; OWZ01051; PHMEG_00027637.
DR OrthoDB; 71507at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00821; PH; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR14336:SF8; DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE; 1.
DR PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|EMBL:OWZ01051.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW Transferase {ECO:0000313|EMBL:OWZ01051.1}.
FT DOMAIN 219..326
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 329..429
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT REGION 450..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OWZ01051.1"
SQ SEQUENCE 475 AA; 53921 MW; 1A6BCBB58D07EB70 CRC64;
LVETRKKQKA AEQIHRDGVA IALAARDYFP LLPKPVTPRA IATRENDDYS VGFDVRQYQL
LRSQPKEKTR TMFGRMSLSR PSADSLSLSY AAYETNKGFA NVDTTLVPSF ASMNPLAQQG
KSSEGQRWQP VPGLYHCKES LYFRSAVGQL LQQAHAEISP TDLEVRANTP EFRVEDGDWV
AHKNQTKFAL DTPQFLNCVA RIPAALIISQ HQVSHAIATK LVSGVLRKRG EGIKAFKRRF
MELDGSVLAY YKKKPEKHGI PLSRDEKKAC ERGCIDLDKV SSLQPMDNKS EPYGFLLVTT
ARTWVLAADS ELEYHRWIKA VCGVVKFNAI HVIYKRQFQL REVNAQAITD VRMAVTTSDT
VGEIVEHIFN CYNQALDAAP LKPYDPTEYL LKITGYRDYM IDRYRILNEY VHVRECLLTK
KTIRLTVVHK SIIRETAMLN LSIRSSLQLA GDPRTNKSSN QLEEAMESER HQSQV
//
