ID   A0A225V8R4_9STRA        Unreviewed;       325 AA.
AC   A0A225V8R4;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   03-MAY-2023, entry version 17.
DE   SubName: Full=Tetrahydrofolate dehydrogenase {ECO:0000313|EMBL:OWZ01692.1};
GN   ORFNames=PHMEG_00026872 {ECO:0000313|EMBL:OWZ01692.1};
OS   Phytophthora megakarya.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ01692.1, ECO:0000313|Proteomes:UP000198211};
RN   [1] {ECO:0000313|Proteomes:UP000198211}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA   Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA   Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT   "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT   of cacao black pod achieved similar genome size and gene model numbers by
RT   different mechanisms.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWZ01692.1}.
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DR   EMBL; NBNE01006662; OWZ01692.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A225V8R4; -.
DR   STRING; 4795.A0A225V8R4; -.
DR   EnsemblProtists; OWZ01692; OWZ01692; PHMEG_00026872.
DR   OrthoDB; 2232005at2759; -.
DR   Proteomes; UP000198211; Unassembled WGS sequence.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198211}.
FT   DOMAIN          11..126
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          148..215
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   325 AA;  36345 MW;  58E42777A49B250A CRC64;
     MADSTSGVKL NASTIAEPFS LAVRSYIDQD MNGVGPKLVG LLAHGDPAAK KYAEWTGKAC
     ARDGIRYELR EVPKDELLEA LEKANHDPEV HGILVYYPCF GAFPSFFGGT MDDFLRDSIS
     IKKDVEGLCQ FYRGNLYRNI RYVDDEKTQK CVLPCTPLAI VKILEHIGIY DKSKPTGNHL
     EGVNITVINR SDIVGRPLAA MLANDGADVY SADIDSLYLF RRGKLIPSEE TQETAEETQE
     TACKKSRVII TGVPVKSYKL PLEWVSENTV VINVASFKNV DEAELLKIKG VQYVPLVGKV
     TVAMLERNLL RLYENFHWKP KKVWQ
//