ID   A0A225VPW7_9STRA        Unreviewed;      1244 AA.
AC   A0A225VPW7;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:OWZ06938.1};
DE   Flags: Fragment;
GN   ORFNames=PHMEG_00020739 {ECO:0000313|EMBL:OWZ06938.1};
OS   Phytophthora megakarya.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ06938.1, ECO:0000313|Proteomes:UP000198211};
RN   [1] {ECO:0000313|Proteomes:UP000198211}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA   Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA   Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT   "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT   of cacao black pod achieved similar genome size and gene model numbers by
RT   different mechanisms.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWZ06938.1}.
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DR   EMBL; NBNE01003753; OWZ06938.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A225VPW7; -.
DR   EnsemblProtists; OWZ06938; OWZ06938; PHMEG_00020739.
DR   OrthoDB; 77488at2759; -.
DR   Proteomes; UP000198211; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   PANTHER; PTHR33064:SF36; RT_RNASEH_2 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF13456; RVT_3; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:OWZ06938.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:OWZ06938.1};
KW   Transferase {ECO:0000313|EMBL:OWZ06938.1}.
FT   DOMAIN          1089..1244
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          886..940
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..928
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1244
FT                   /evidence="ECO:0000313|EMBL:OWZ06938.1"
SQ   SEQUENCE   1244 AA;  140082 MW;  7F45733B8CC8BCEC CRC64;
     MEPVARSVDG ATDGSPVGDD PVSAAAALGA SIPTPTECLN IDCGCNNPPT ETHSEEKSPD
     AAVADLEHTF MCVMHVLSTE GNDDLTDDDY APSVTELDYT APNVKNPIFV GDQQRRLDEV
     LKKHEAIMIL SGNVLPPPAY GVVCDIDVQG HAPIKQRARR ILLRHLQKLY ELLKGLLKAG
     PIAFSDSPWA SPIVIVLKKN GQDIRLCIDY KMVNAVTAIM EYAMPLVDDL LTELENYLWF
     CSLDAASGFW AIMMTMRARK ISVFVCALGY FGWLRMPFGL TNAPMIYQRM IDNALWGFVQ
     PKGGWKRYDE RMKLAEKAAK HQRSLDGDSY FTLTTTRTKF EADRHASSEL DPVLRVVKDP
     YTDMFGTNEP AESSLVPVFQ RRSFVDGICF SGTTFDDCLD TLDQLLARFE ECRISVSFTK
     IIFCQSKVDF LSNEVSPEGI RADPKKMTAI TKLPFPKSKK GMQQFLGSLN YYSRFIQDFA
     VYGAALYQLK EEDFYDGGDL AAAKESFFAL QRKVADAPFL RHFDDKKERN LDADARRQTT
     PCPLLRTSSQ GRRDDHSAEK EVLALLLLLK VCYTQLAGKT LHVYTRFSTL GWVHKSKSLF
     GRVVQFAVLL SPWQLEVQRV REKDCVFTQL LQSTITNFVN LDDSLALVAP PTKGSPSTKL
     DPSLLYAQLP HDYEGFVVSF DGSAKTEKNG GYGSCSWIVW KLPEWQIVIA ASAYIEQTTV
     IMAEYSGMNH GVIVALEHVA EDLVIVGDSR LAIQQSLGVI ACRKDSLMTL LHPHREVVAK
     LKLVRNLHVV REYNAAADSL AGEALESKVS KVVLNDHRKT ELKELNRIQE MIYEPSSDEI
     KVENASSESF AQIPDGKTRY IHAMDSDILL QRKTYADCAH QERAEVSATT RSQTKTKKKR
     VHFENEVPEG TTNTEATEAV NENSETQEQR PSAEARHELT ADDIDPVTVQ EERRIAKAQD
     EEFRGSNLKA VLRGETTGET TAMTYKEARE AWKWADNFVL SSDNVLYYTG VSRRKVDENQ
     PEMSLRLVVP TTMIQEVLYN CHDSVEGGHH GVVRFYQSKN VEKHVKSCLD CGSSKSLPQL
     RGYSPGNVLA ERPFQVVSMD FVIPLPRSRR GNTALLLWHC SFTWFIIAKA MSDTDALTVV
     KVFEERIYRR FGAPSLVRHD RDPRFMSEVF QAFAELIQAR SRSTLSYRPQ ANGQQERSVK
     TVMQSVKVYV EDPLQQDWDE IAERLVFAIN NSHDMTRKET PLYL
//