ID A0A225W4T6_9STRA Unreviewed; 782 AA.
AC A0A225W4T6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PHMEG_00014457 {ECO:0000313|EMBL:OWZ12394.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ12394.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ12394.1}.
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DR EMBL; NBNE01001860; OWZ12394.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225W4T6; -.
DR STRING; 4795.A0A225W4T6; -.
DR EnsemblProtists; OWZ12394; OWZ12394; PHMEG_00014457.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OWZ12394.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211}.
FT DOMAIN 7..289
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 782 AA; 88784 MW; 9436B2EA82F95A0D CRC64;
MKVDIDGLEV LFPYERMYSE QLQYMRELKR ALDAQGHCML EMPTGTGKTV SLLSLVLAYK
HAHPTAGKLI YCTRTVPEMA KCVEEIKKLV QYREQHYGPK AQVTAVCLSS RRNMCVHPRV
MAHADGEDVD GQCRKMTASW VRAKATKARE EGEQQQVETC GFYENYDTRK SDDTVLPAGV
YSVDDLKEIG AQKGWCPYFL TRYVVTFADV VVYNYQYMLD PKVSQLVSRS FEKESIVVFD
EAHNIDNVCI EALSVDLDRR ALDRASRNLT TLSSQVNKLK QADKTRLDAE YRRLVDGLRS
SNAIVAPTYT DATTNNAIDT SNDILIANPV LPDDVLDEAI PGNIRRAEHF VAFMRRLIEY
LRQRIRVRQV ESETPQAFLH HLHQAINMEI KPMKFCYTRL NSLLRTLEVT NLEEYNSLTD
VADFATLVAT YAEGFMLIIE PFDSASGVHD PVLQLSCLDA SLAIRPVFER FSSVIITSGT
LSPIDLYPRL LNFNPVIRES LPMSVYRSSI CPLVITRGSD QMPVSTKFDL RDDLSVVRNY
GTLLLEMAAC TPDGMVCFFP SYLYMEKIIG QWDSLGVLKR VLGSKLLFIE TKDIVETTLA
LDNYKKACDC GRGAIFFSVA RGKVAEGIDF DRHYGRAVIL FGIPFQYTLS NTLRARLEYL
RYTHQIREGD FLTFDALRQA AQCAGRVLRM LRSKTDYGLV IFADSRYNRA DKRTKLPPWI
TQFLVDSHLN LSVDMAVFMA KKYLSLMAQP VDEATNVNSI LLDADGVSKW LGRHPKEDEP
MQ
//
