ID   A0A225W5L6_9STRA        Unreviewed;       551 AA.
AC   A0A225W5L6;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=RNase H type-1 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PHMEG_00014362 {ECO:0000313|EMBL:OWZ12469.1};
OS   Phytophthora megakarya.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ12469.1, ECO:0000313|Proteomes:UP000198211};
RN   [1] {ECO:0000313|Proteomes:UP000198211}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA   Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA   Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT   "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT   of cacao black pod achieved similar genome size and gene model numbers by
RT   different mechanisms.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWZ12469.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NBNE01001837; OWZ12469.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A225W5L6; -.
DR   EnsemblProtists; OWZ12469; OWZ12469; PHMEG_00014362.
DR   Proteomes; UP000198211; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   PANTHER; PTHR33064:SF36; RT_RNASEH_2 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF13456; RVT_3; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198211}.
FT   DOMAIN          252..339
FT                   /note="Reverse transcriptase RNase H-like"
FT                   /evidence="ECO:0000259|Pfam:PF17917"
FT   DOMAIN          408..526
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|Pfam:PF13456"
SQ   SEQUENCE   551 AA;  62086 MW;  FBD38778D525B14D CRC64;
     MVNAVSPIMK YTMPLVDDLL TELERYLWFC SLDAASGFWA IMMTMSARKT LAFLNQRLPN
     DDSDFTLTTT RTKFEADRQA SSELDPVLRM VNDPYADMFA TNEPDESSLV PVFQRRSFVD
     DICFGGTTFD ECLDIVDKLL ARFEECRIIV SFTKSIFCQS MVDFLSHEVS PEGIRADPKV
     TVITKLPFPK SKKGMQHRFI QDFVVYGAAL YQVKEDDFFE GGDLVAFKES FTALQQKVAE
     APILRHLETK KEVLVMLYAN MHDDKLHPVR FCGRVLKDAE MNYHSAEKEV LALLLLLKVC
     YIQLVGKTLH VYTRFSILGW VHKSKSLFGR AVQFAVLLSP WQLVVQRLWE KDCVFTQLLQ
     SASTYFVDLD DSLALVAPPT KGSPSTRLDP SLLYAQLSHN YEGFVVSFDG SAKTEKNGGY
     GSCSWIVWKL PGWQIVIAAS AYLEQTTVNM AEYSGMNHGV IAALEHGAEN LVIVGDSRLA
     IQQSLGVIAC RKDSLMTLLN RHREIVATLK SVRYLWCYNA AADSLAGEAL ESKVSKMVLN
     DHRKTGLKEL N
//