ID A0A225W908_9STRA Unreviewed; 444 AA.
AC A0A225W908;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ethanolamine-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00024221};
DE EC=2.7.7.14 {ECO:0000256|ARBA:ARBA00024221};
DE AltName: Full=CTP:phosphoethanolamine cytidylyltransferase {ECO:0000256|ARBA:ARBA00031473};
GN ORFNames=PHMEG_00012720 {ECO:0000313|EMBL:OWZ13884.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ13884.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC {ECO:0000256|ARBA:ARBA00024191}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ13884.1}.
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DR EMBL; NBNE01001472; OWZ13884.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225W908; -.
DR STRING; 4795.A0A225W908; -.
DR EnsemblProtists; OWZ13884; OWZ13884; PHMEG_00012720.
DR OrthoDB; 5474784at2759; -.
DR UniPathway; UPA00558; UER00742.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd14686; bZIP; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR044608; Ect1/PCYT2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 2.
DR PANTHER; PTHR45780; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR45780:SF2; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:OWZ13884.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OWZ13884.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..217
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 280..373
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT COILED 49..76
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 444 AA; 51347 MW; FB7CC13D322D390B CRC64;
MGHAHELFAR MGFPEPYPDA ERLAIALLTG VFTLLAYFVL FGKRHRRRRK VLQEDLEKAY
QKVQELQDRM AQMELEEREE PPKEQIRIWM DGAFDMMHYG HMNAFRQARS LGTYLVVGVN
DDESITACKG APPVLNNEER IASVEGCKFV DEVEPHCPYI MNEEYLQRMI KKHRIDYVVH
GDDPCIVDGK DVYESAQKLG KYRTIPRTEG VSTSDILGRM LVMHKTHHTH DHFAANGQLS
SRMLQEKAKE RPSKFLTTNR MLRLFSVGNH EPLKTDKIVY IDGAFDMFHA GHVEILRLAK
QQGSYLIVGV HNDSVVNAHR GLNYPIMNLH ERVLSVLGCK YVDDVLIDAP WQVTPEMVAS
LNISVVVHGT HRDQHHLPEF SLEEHYEHAR KAGIFKLIQS PIKLDVNDIV ARINDNRERF
EKKFVSKMKS EEEYYADRYG KNKK
//
