ID A0A225WA90_9STRA Unreviewed; 1367 AA.
AC A0A225WA90;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OWZ14324.1};
GN ORFNames=PHMEG_00012214 {ECO:0000313|EMBL:OWZ14324.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ14324.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ14324.1}.
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DR EMBL; NBNE01001364; OWZ14324.1; -; Genomic_DNA.
DR STRING; 4795.A0A225WA90; -.
DR EnsemblProtists; OWZ14324; OWZ14324; PHMEG_00012214.
DR OrthoDB; 53554at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR CDD; cd00821; PH; 1.
DR CDD; cd00160; RhoGEF; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF01363; FYVE; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00064; FYVE; 2.
DR SMART; SM00233; PH; 3.
DR SMART; SM00325; RhoGEF; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 99..317
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 346..456
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 493..555
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 696..979
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1004..1276
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1300..1360
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..86
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 152344 MW; 277E25675C1A318A CRC64;
MSSTQQVEAA ETPRVARRKR SGKSSRKKMT LRPGVVLFDP KDLVVSSTST LTVEMLEDNL
EDNQEDDQEE ENAEDNQEET QENNEDVDPD SPAAKQARLR ACVIEEICET EKSYVSDIST
LLDHYIVALE DSKHRIMEDA QIAVFFNNLR HLVMLNSKLL TDLTDIKERR ASMVAQKKPS
GESTTTNGKR KKSVNSPVAV AVQLEAEGVG AVFCRYAPLF KLYGGYAKDY EEVAALLQNF
GRDAKLGFTR FLEVCRERSG STKQFESLLI MPIQRIPRYK LLLERLCELT PPEHPDAAFL
TEAVDRVRAA ASLINETVRR QENLETVLQA QQKFSGQLSL FTADRRIIKS GKLMKMSTKR
QEDVMIHLFN DILLYSGVLI TGGYRVRRIV HLHSKAVGVK SELPPALQAI FDQPTRSRVR
KDCGFVVTSR EKTFILFTET PEVQREWVEA IAGAVKEAQK KKRAELGDAV DGDENHPESC
EGPADAAALW VPDEVVESCA ICSAASFRAY YRRRHHCRRC GAVVCDTCSL GRAPLFVGET
TRAERVCSPC FKVLDLVRQI ALHWLSRVVE FRGVLRRRRF NKWTEHYYEL RAGVLKQFTV
ETASGSTPVD QSGNAPGFGS SGNGSSNGPA SSSGADQSPT SSLVSSSTSA VASVHESEWI
LRRMSSLDRG RATDDLSMEL AHATGDDRDA YLLERRRRQI LKEIIRSEES YVQCLGECIR
LFVQPLLLRQ LEGRQMFRRR QNKRRGSLRP VLGGTLTSST RQSPNHRRMG SNGNAVITRA
VGSSASLHGM ISASYGAAAA AANSATTSSP GPNMLVMDAD LSIFFSSVDQ IYTLNQQLLD
HLSRHLEETS PALAPSQGQN AQREGEPVEF PGVKVHRAGA IFHAYAPLMQ LYTSYASRHS
SALTALDSPE FAGFLSELPS EADENSLRRY LNMPVERIPR YKMLLQELLG STPPEHVDFA
PLQAAIHSVD RVASKIEEIS ERRENARRLA AVSAKVGIDL SGRHFIRDGM LRKVCRSKVQ
TYYFVLLEDA MVYGRQGGLH KKFRLIDLWE CKVAEDTEAM PGVITTVVNS NNAFCFYSPL
KSFILLTESE ADKVGWTTDI RVCIDRNLQG KTHPRRTSVR SDGLAENDED SSSGYELEGG
FVIKNGWLNV SGGAVVTGNG ATSPSNSSSV GKKPRRLWIT LTLQTISLGS TFKATQPEET
IPIELCEVAP LKHDKCFRLQ FLHDTLCEVA PLKHDKCFRL QFLHDTKTRA QTTYVFEALS
LVEREEWVRA LTHCISGGDE LDLRRRSLKA ATLAPIFMFD KVSNVCTICT HSFAVYRPRH
HCRLCGSLVC GNCSKRRWTL SYSSSKKASR VCDSCAESAM SISRSIA
//
