ID   A0A225WKC1_9STRA        Unreviewed;       757 AA.
AC   A0A225WKC1;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:OWZ17569.1};
GN   ORFNames=PHMEG_0008485 {ECO:0000313|EMBL:OWZ17569.1};
OS   Phytophthora megakarya.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ17569.1, ECO:0000313|Proteomes:UP000198211};
RN   [1] {ECO:0000313|Proteomes:UP000198211}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA   Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA   Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT   "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT   of cacao black pod achieved similar genome size and gene model numbers by
RT   different mechanisms.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWZ17569.1}.
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DR   EMBL; NBNE01000733; OWZ17569.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A225WKC1; -.
DR   EnsemblProtists; OWZ17569; OWZ17569; PHMEG_0008485.
DR   OrthoDB; 49911at2759; -.
DR   Proteomes; UP000198211; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF13456; RVT_3; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:OWZ17569.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:OWZ17569.1};
KW   Transferase {ECO:0000313|EMBL:OWZ17569.1}.
FT   DOMAIN          215..305
FT                   /note="Reverse transcriptase RNase H-like"
FT                   /evidence="ECO:0000259|Pfam:PF17917"
FT   DOMAIN          360..479
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|Pfam:PF13456"
FT   DOMAIN          657..710
FT                   /note="Integrase zinc-binding"
FT                   /evidence="ECO:0000259|Pfam:PF17921"
FT   REGION          509..538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  85321 MW;  20CB3C79C2C89940 CRC64;
     MTERAKLISA FTCPFGHFQW GFVRLSPEEE ALVDQDVLDY LRLNSQVPGD KMDVERMTPL
     VEQMTVFRSN IPTPSQMGRG LGRSSYIDDI VHGGAPWNQL CGDLDALLYR LRYWGISVSL
     PKSEFGKRVI PYLSHEIGAE GIRAIPKIVK AIQELPFPSF LKGVQSFLGS LNYYHKFIED
     YAEVAAPLYE LTEDQVRAGR DLSRAKETFE TLKRKITACA VLGQIHDGLG QSVRFTGRVL
     NDAELKYHIA EKAVLAVMRV LHVFKHLIEC CPLVTYTRRS VLKWVINSKT AESRLVPWGF
     ALSQYDREIR KVCRDEDGLA AIMGTGITPR EQLDEVAAVL IPAKGRVKLP PVYSGVVLSF
     DGAAKTSTRK GSCGCILWQL PEWKVLDARE YILDGVTVND AAYFGLLKGL VMALGRGIQD
     IVGDSRIVIQ QVQGLINCNQ PNLQRILAEY ETLKRRFQTV RLVHMKREFN QATDYLVSKT
     LVQGEAWTVQ DDLEKRHVEV VSKIHEQLVK PSEGTDTQVR SGDPIQDSGK EDGNSGMRYG
     PGPECAPLSS AARVMTVLTR SRAQEADGNK IPPMGTLEFQ AERWRRIRVH QEDDEYLAEL
     RAFLNDDLDK FSPSRLKKIS KAADRFVLDD RGILYRLPHS LRGRPQDAVD NLRLVVPSLL
     RADMLHEEYQ GGHQGITRTH ERLRTEFYWP GTYADVQRFV KECVYCASGK GDPPNAGPSP
     EDIEPRCPFE TVSMDFVTHM PEGTLSSCYL RTCCRVT
//