ID A0A225WKR5_9STRA Unreviewed; 2658 AA.
AC A0A225WKR5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=PHMEG_0007605 {ECO:0000313|EMBL:OWZ18321.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ18321.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ18321.1}.
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DR EMBL; NBNE01000605; OWZ18321.1; -; Genomic_DNA.
DR STRING; 4795.A0A225WKR5; -.
DR EnsemblProtists; OWZ18321; OWZ18321; PHMEG_0007605.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF11865; DUF3385; 2.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1393..2022
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2200..2513
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2631..2658
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2482..2570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2510..2524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2658 AA; 296765 MW; A6B08AEB8EC35597 CRC64;
MADSFTRFLP GLRSSNSSVR HRAAQSLRHF IESESRDLSH GLYMKWVTDI SARLMLLCNS
NENADRMGGI AAMDELVELF IAERNDQTII EFAHSLTKVF EKIPSADPPM LRVAAKALGH
IVSTGGTSLI EFVEDYHVKP ALEWLKNETF HVRRHAAVMI LKELSINAPS TSFRYMDKYF
DFIWSAFWDS KLVVRVSASE SLQTCFMLIQ QRESNRKTSW YNRALDEAES AFKRNSSDAT
HGALLILNEL LRNTGDFMHS HYGRACRLVF SHQDHKSATV RSAVIGLFPR LAKFNTSVFV
EKCYRPCMNH LLEVLFSATT TTRPDALLSI GKLSLAIGPL LARDEQALMA IMNGIKGGLQ
VRKKDFDTHR EALACLRMLA ETVGPALIRV DLESMVGPLF QNDLDSSLVE TLTTIVKKIP
PMKPIIQQKL FERLSSILRS RQNDVTGTAT TPTSRKLKAA SISVTGGMLS NLFLSATGSK
ASSSENGAPS TEVSSAISMQ ALALETLANF DFQGNRLIPI MSFVHETVVK FLDHEVATIR
KSAALTCCKL LLPQGEDRGG STAMTSEDFA RPVTSVLERL LTVGIADNEA SIRLRVLASL
DSRFDPLLAL NDNLRCLFIA LNDEVFSIRQ TAMSTLGRLT HHNPSTVLPS LRQTLVQLLA
ELEFSGDSRG KEEGALLIGC LLRSAAQLAQ PYVLPILRVL MKNLREDSER RSHSRSTVSV
SKAILATLGD LAEVGAQELT PYLGQLLPDV IDEMRDSSNP QILQVAIKTL GQLVSSTGYV
VLPYHEYPEL LDLLCQALQK SGDPFESLRI EAGRTLGVLG ALDPYNLRLF HLQKQGKLTD
AKKKEFRSSA FAVGAGGVFS LMTNTTNPTE SLATNGFGSG SGAAKGAVIG IRIGNGIGGP
GMLDGSSEED AQQLGESLLL TPARKVTKSD KQTSGKLTNI ILEVPPDDLL PSMIPDSSQY
FPTVAINALI RILLEPRNSV HYQGTFMAIM YICKSQRKRM GQHLDKIIPA FLYALEKVNR
SLRKFLFEQL CDLVQIVEEQ IQPHLDHVAL LSIISSYWDE HLEEVLNLVK KLANSLGENF
RVYLPDLIPQ MLRVIRTERD NPARPRTLLV LKTAVSLGRL LDGYLHLIIP ALVALIQSDA
DINARKQGLG SLGSLVKKLN VSVYASKIIH MLARVISSQP EMVYLAMDCL CCMVYTMGDD
YAIFVPVISQ VLGRHTSRSN DIFDRYDLLV SKILKYQPLP VASWATDPLK SRVDTSSAHK
DSSSSAQDET KSLPCDQKNL MKAWEASQRS TKEDWNEWIL AFSVELLRES PSPVLRACKE
LASVYQPLAR ELFNASFVSM WPHLSSSTQD NLIRSLESAF QSPHLPSEIL QTLLNLAEFM
EHDDQPLPID IRLLGSLADK CHSFAKALHY KELEFNTNPS TDGIQALISI NSKLNQPEAA
RGILKYALEK LPGIEVKASW HEKLLRWDDA LATHDRVLQE DPSNVESIFG KMRCLWAIGE
WRKLNDHVQQ TWTKIYGEGQ DLKREQVDGE KLLDVAPALK KELCSSGARV AFSLQNWDSI
PKYINSDMDA TESHLFKAVV SIRRMELDEA MSSITDCRKE MDPTLRSLVS ESYGRAYLPA
IVNLQMLTEL EEIVAYLKAF AYKNNGELTL LSTPVPSSTS MSTTASRRKQ SISSLNFVSS
SSSTSYGHEK KVALKKLQTI WTRRMLGVER NIEVWQSLML VRSLVFDPRE DVDIWLKYAR
LCLKSGHINL AASALWRVGA QPFIRSVERD PYTPIPINLG GNAGASQGFA NGLLSLADSA
AQDPRVAFSY LRHLWAENRE DVALKQMDYF IEALEQHGDP TDEDMRKLRV QVYIQLGEWQ
MSLNEQASGA YDHVLECLET ATKLDPTNDR AWHEWALMNF RALEATVKES GFGDPKRYAV
RAIQGFFRSI SFGHTSYDVT KDVLRLLTLW FAQGNRSDVH TAMVEGFQDA SVDTWLDVIP
QLIARIDTPN QKTSELLHDL LSRIGQAHPQ ALIYPITVAS KALNPTRKHA AEGILAAVRR
HSSQLVYEAD MVSRELIRVA ILWNELWHGA LEEASKHFFN NRDVTAMIAE LAPLHEQMDQ
IGTEETPTLR EVAFYQAFAR DLQYAKEWTN VYERTKSLDD LNQAWDIYYS VFSKIRKQLA
NLSTLELANV GPKLLSVRGL TLAVPGTYKA GAPIVRIQSF DTKVTVLTSK QRPRRVAING
SDGKAYPFLL KGHEDLRQDE RVMQLFGVIN TLLANDSDTS KRNLAIERYS VLPLSHTSGL
IGWVPNCDTL HQLIRDYREA RKIQLNVEHR LMVQMAPDYD KLPLMQKVEA FKYALGETTG
QDLYRVLWLK SQDSEVWLDR RRNFTRSLAV MSMAGYILGL GDRHPSNLML DRVSGKLVHI
DFGDCFEVAM ERDKYPEKIP FRLTRMLTQA MEVSGIEGNF RYTCEASMRV LRDNRDSLMA
VLEAFVYDPL INWRLLKKDA VPSHAQPEED DGAAGGGRGG AGAADSVDAH GHRNSSSAGN
EDGNDTNGDG DDDNANGDNG DEDKLAEGSM KSSTSSAPRR RRHSSSEAML GYNMDMLDSA
IARNSISETQ RDNFGTSFVA AEHPQLNEKA LSVVDRVKKK LAGRDFDDGS RVLTVDAQVD
RLIHQATSHE NLCQLYYG
//
