ID A0A225WU88_9STRA Unreviewed; 924 AA.
AC A0A225WU88;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Peptidase M12A domain-containing protein {ECO:0000259|PROSITE:PS51864};
GN ORFNames=PHMEG_0004236 {ECO:0000313|EMBL:OWZ21234.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ21234.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01211};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PROSITE-
CC ProRule:PRU01211};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01211}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ21234.1}.
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DR EMBL; NBNE01000244; OWZ21234.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225WU88; -.
DR STRING; 4795.A0A225WU88; -.
DR EnsemblProtists; OWZ21234; OWZ21234; PHMEG_0004236.
DR OrthoDB; 48991at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001506; Peptidase_M12A.
DR InterPro; IPR006026; Peptidase_Metallo.
DR PANTHER; PTHR10127; DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING; 1.
DR PANTHER; PTHR10127:SF850; METALLOENDOPEPTIDASE; 1.
DR Pfam; PF01400; Astacin; 1.
DR SMART; SM00235; ZnMc; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS51864; ASTACIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01211};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01211}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..924
FT /note="Peptidase M12A domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012375380"
FT TRANSMEM 875..895
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 599..822
FT /note="Peptidase M12A"
FT /evidence="ECO:0000259|PROSITE:PS51864"
FT BINDING 696
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT BINDING 700
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT BINDING 706
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
SQ SEQUENCE 924 AA; 102634 MW; 4264F72D1D3761D8 CRC64;
MVFARFLPAV LCGLGFVGWG AQAAFYVCPE GCTAMLLPRD MEMIDDCVCD DGVDTTAEEA
AADAVDNGAF SCKGRYKPKR GGVPRSVADC DCYHPYEKDS KTQECVLTEC PRAGNYEPKP
GVREVASLAD CTCTSPYVKA ETSGQCVVGD NAQTQTRGRF QCPPNSTPTP DIFPKSFADC
HCSWGFVRNS FDQCEREYAA YVCPVNSVKR SDLPIGERPR GFFDCECLST GEYHRDEEAH
ACWPVSQMKA RKPKRQHDYI RGDNAEEQFT NFEVVDREAK PYQCPPFSRA VATVPHSVEQ
CQCIPGYAWK TPEMTCVRTS GYKCPDHAYK RTKLHGSEME SSFEDCACAR GYFLDAMAER
CVPWMLANSN SCPPFAVLTQ WPLQSNANCK CVYGLNETIS EEEDEARRKA EAEEILNGGT
AQETPPMRRR KKECNTRPTD ISLPDFSQCP HDSMATMWPV ATADACTCLS GFEKTPLSEQ
EISRGVGDGF HCVATPEKNL VADEAAAACH APGVIHPLSG ECRLPIEEIL DEKASKKGGK
PEGVLFKGIE YDYELVDNTV MIIQGDVAIG ERFVWQDVDP TDPEEVTTRI EHVLHGYYNS
GRDHRWSHER MCFQVDKSAR PFLRTLLSAT EHITHATGFK FHRCGGDNCR TDLSCRSHDF
VAVQGVESSC YSFIGRIGGP QRLGVSADCG LGNVVHVLLH AVGLRHTVDR VDRDDHVRIA
WECIPESKRS YFVVEDMNSA PTPTRAADRI LDPPPYDLFS IMHHPPDAFV HSVSGDGKPQ
WCPSVVPLIA DDTKRLAVMK DMGQRERMTT TDVRSVWALY PGLKKKHHSR QKDVESGEAE
VEELHDTFVH TEQDAVETAS ATGHGTQHRS FGQRLVSFLG AVVTLVGFGA LLAFITTELR
RRALLSSGDD FFYEAPLIDS KNDI
//
