ID A0A225WVZ5_9STRA Unreviewed; 3120 AA.
AC A0A225WVZ5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Phosphatidylinositol kinase {ECO:0000313|EMBL:OWZ21835.1};
GN ORFNames=PHMEG_0003559 {ECO:0000313|EMBL:OWZ21835.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ21835.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ21835.1}.
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DR EMBL; NBNE01000185; OWZ21835.1; -; Genomic_DNA.
DR STRING; 4795.A0A225WVZ5; -.
DR EnsemblProtists; OWZ21835; OWZ21835; PHMEG_0003559.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 2.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:OWZ21835.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198211};
KW Transferase {ECO:0000313|EMBL:OWZ21835.1}.
FT DOMAIN 1902..2439
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2735..3067
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3088..3120
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1003..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3032..3059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1451..1469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1533..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3032..3049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3120 AA; 348062 MW; 00B730F3E41815B7 CRC64;
MNVEVVRQKL VDGDPDAVLK ELVDMYRRAE ILHTPQLGRI LEALFPVWKG LLHSKLTPQL
RATTQNRCRK VLLQILNRLP SNETLRPYVT QLLQLLMEVL QKDNEDNALI ALKTLFDLHR
NYRPALRNEV QPFLELVQLM YKNLQTTMKK QFSVVRAILS RGELAYLGLR TLEFWVDNLN
PDFLYPIMTS QDRLLTEIIE ALNTHLIPPP YPYGELAMRI LGKIGGRNRQ YLMDPLNLNY
HEHSFTGLTF TFSWDEDGNS MDIDMNGDGD ALAQGSMFPM KMDVLVVQAT KALRTYLRKT
SAERNNFSKA DSRLADTDEF EETETLTRPS FLLEKDDKTL QLETETMGKI PVVSLNVNYY
ANDDQDTVET DAEDLDSVVE ATFNAALKIN ASGVGEVKSS VDVSNDAKMQ AQIQLNAQKA
AAQAVASAQA QGMTVSAAEA RGVQARAAYI VKAQAQVNAQ QALKVQSQVQ IQANAQKLHA
QTLAAAQAQG LSLVQAQAKA QFASKDYIAK AQSHISSASM QASLPSPAMS SLVTQQQAQQ
LQAQIQVNAQ KVHAQALATA QAQGLKPMQA QEKAKQAQAT YVHRANAQAQ AKIARAQSQG
LTSSLVLGNN SSSTSGGPFA SKAQQEALEL HYQGLRLLRS ISKLHPAWLA SQTVIIDCLR
KLWRSSARVQ RLVVHDRLPI KFHLESKLLI KCMITYSRAK PEDMQVLLDM VSVFLHRTPF
DFSFLQTFYR EEVAVKYSAA NKRNLIRLFL RMLREQGASE ELKVHAAQLV IMPVLTTSFE
DPSVNNIDVM DLDTVMWMLR EILASKDYPP EAMQSLRIEL LKLGTLLIQH MSKYVTDHRK
EVIKFAWNHL KAHDLTSKLW AYVNVCRFIS VYDTPPKIVL QVYVALLRTH EMDARFLVRK
AFDILLPALP SRLPSNEFIK AIKWTKKIAY EEGHVLGQLV HIWFLIVRHP ALFYPFRGQF
VPLMVNSLNR LAIPPSSTPD HRRLAVNIVD LVISWEQTRQ NRLAMRGASS GPKTPSGELK
RSPSTMTAAS SEKTSDGHAS KKRKVLTSEG TDAIEVKSVD VQSSTKADGD GTATLQIQVP
TQTSTVGSNQ QGQVAASPSL ETNRAANNED DFELSGAMVD LVINFAFRFA LASADKQDTS
RLAKTCGELF DKALRLWPSA SIRFSYFDKL IAVTAESVIR QQQQLQASVN AAAAAASGTG
QVPIPAPPPP TVMPPFFVVP KGAPLFSLAI LDAVLGILNS LITPEVVTKS KRPIAYVIQY
APRIMKLLEP CFDRQNHEIQ ASLTKFLRRM TEVLVCKFYP WLREIINERL VNAGMFQQDL
GTGGVSLPGG QSVASSKSKG KNPAQSSIGA KTDKQGGASS NAAAGHVHTS GKHQKDLNPL
INHEAARMRL LFSQHPRVVV SPTSYPGEFT LKLLSGLAEI TPEFVDHFAP ALLKLAQRFT
REHLIQSAAA GGAGSQGSKH GGSNGTAMGV ESGQAVVDSF GRNRVMATPS LAIVHEWDQM
QSGRSNLAVN KVVRHAVKKN ENPGEKSAAK KKGSTNDQSL GNESSNAKGG STMKKKMGTA
ASSSMLARSG IVGGNNKRPI ELLVLCYALL AKCTFTTAEH RRLYTNLLVH CLEGSYNIPL
LLQITKIVAK MVASKDARHQ VLTTKDKMTL LNKMSTFDRL NEISALPLNE EYYQLVLKLC
DPPSGDAKHH ASQLHLSPTP QSHSLTTHFM AGLLAPDPVT REKFLQIFFA ATDPGPVARL
QLVLRQDWQA CGTRYWPVIA IETLMAAISP ATPPSISTMQ DPVSMGNATT TKCQARAEFL
ESYGQVKSSD LTLALRDLAH VDLELAKELW VSLFSAAWGL LKEADQTQMT SQLLKILASK
YNKRDLNVPL GASAPRRTNV VQTLMKGIVS TSPSAPAMTP ELVLHIASAY DVWSCAIRLC
EFQVEKSNLS VESRLRWIEA LSAIYKQLSE DDLRIGLSLE NIAQPETRTA LALEALGCVH
EAQEEYFRAL SKAQSGRVSV EDVNLFELRL WEERWVGCAK QLCQWQLMND FAKSTQNQEL
LLDCAWKRGD WASAKQLLLS PSMQSSAELG CPQTRLQRLY ISILDADKRS AIDTLASQTA
ELALHQWQGL PRILSRAHLP LMHLFHKFVE VKESIQMMED IKSASSQHAA LPNLKPSINT
WRERLPNKWE PILLWDDILT WRSHMFQVVK TTFAWSDAQV LACMHDSPWS VIKLAHTARK
QRLPDVCLGA LAKLYSVPAM DVQDAFSKLR EQVSICYESA TEYSGGLSIL NTTNLDYFSL
RQKAEMFRLK ALFLEAQGSL PEANQTFSHC LQICDSYGKG WLSWGHYCYR LFLVRKDLAL
ASQTIACYLQ AIHHRCNSAR LMIARVLWLL NMDDRRGVLI QAFETHGKQL PIWIWIIWIP
QLLMALGRPE APQIRGLLRG LSAKFPQALY YTMRAFFLEN RDNAMMLANQ QQLAGGVSPS
ASAASPPGSR SYYRTKSGHV VGVPSSMAVA QVQEVPGLVG PARPTPAAFN AAPGSVLTLE
AWTEKVRNNG GDGHSLKAEV GPVQYTEDLL NFLRRSHDSL TFEMECMLEE MITRFRPEPE
EELLTAVHAL LLKCYQLPRL TKTEPVPKML RAALERVCRK LFVLLPHQKN EKHEAFVEEF
KDAFERDFTP LGDDEEEQHA QAASTLYDIM NRLKRWKSLL QLRVKKVGKR DAGKLYLEQC
SRHLMELSSS NMEVPGQYVS DSEPIKDLHA RIQHFESTVD VLLRNGFTQR RVSMGGSDGR
PYYFLVQYAM THITRTDERM MQMYLLLNRL LFRHKETKKR NTVFHVPKVI PLTPRVRLLE
DNRDFVTLGE IYELDCQIES KDPDLPVELY REHVSEAYAE AGNNSSKPEE ERVAEAKAHA
FQEICNEHVP ETLLAKYVHG ISAHSDAYFQ FRSEFTKHLA LSSFLSYALF VGDRAPHRVL
FSRRTGRVVS TELRPGYASS GILEAATTMP FRLTRNLHSF MTRPGVQGSF SVGMGAAAEA
LMSEEDILSN QLCLFFRDDL LSWHASKTRL QSLDPQAGRS SSPGGSSGPA SPALGQRRVE
AQVQQRVEAN VGLVLERIRG VSLKKETGGS SRGKSVQELL EIATSPERQQ EMYPTWYPWL
//
