ID   A0A225X068_9STRA        Unreviewed;       465 AA.
AC   A0A225X068;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN   ORFNames=PHMEG_0002549 {ECO:0000313|EMBL:OWZ22697.1};
OS   Phytophthora megakarya.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ22697.1, ECO:0000313|Proteomes:UP000198211};
RN   [1] {ECO:0000313|Proteomes:UP000198211}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA   Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA   Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT   "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT   of cacao black pod achieved similar genome size and gene model numbers by
RT   different mechanisms.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWZ22697.1}.
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DR   EMBL; NBNE01000116; OWZ22697.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A225X068; -.
DR   STRING; 4795.A0A225X068; -.
DR   EnsemblProtists; OWZ22697; OWZ22697; PHMEG_0002549.
DR   OrthoDB; 63705at2759; -.
DR   Proteomes; UP000198211; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198211}.
FT   DOMAIN          23..40
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          192..203
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   465 AA;  51803 MW;  DA1FDA35E1BA8029 CRC64;
     MTQGFHQKFV QIHTTYANGL EAHKSCMFVY WHRMLLLGYE NMLRSLSPSY ECITVPFWDH
     LSGTAQQAAS TCSTIENCSP IIADFGGTTT GLSKSLIVYN TSIAYTVKSI CVTQGVAGQF
     CGNNTGCANC IMRMRSRYLG TYPAEATFGS VYQQLFTYNY WENVTASLEN GIHNSIHNAL
     GGVMAYMQAP VDPLFYSHHA LIDLLQTIYV KCQLGDEKTY ISAASKSSDP RFWSSCAKAS
     GSNYTGADTI SMRVTSANDS KTYVNAWQDP NNILYPFFKD LPYTYGDYID AKDLGSYSYT
     YEISGGLANM YQNCSASNTL SSSSTLLADE QQGTVVKNAV LPRRKNPLIP TIVDGTDEDD
     ATRRWNTVLF EIAKVLGFED WAAHEQVETI TCLHHAECIG PVEDYTYLYR ENFGIEGHTR
     CFSIIGDLVA GNRIISIPKW RKITRRFLPC PLRDGEMATT VSTTE
//