ID A0A225X4L3_9STRA Unreviewed; 657 AA.
AC A0A225X4L3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=phosphoribosylaminoimidazole carboxylase {ECO:0000256|ARBA:ARBA00012329};
DE EC=4.1.1.21 {ECO:0000256|ARBA:ARBA00012329};
GN ORFNames=PHMEG_000278 {ECO:0000313|EMBL:OWZ24602.1};
OS Phytophthora megakarya.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4795 {ECO:0000313|EMBL:OWZ24602.1, ECO:0000313|Proteomes:UP000198211};
RN [1] {ECO:0000313|Proteomes:UP000198211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=zdho120 {ECO:0000313|Proteomes:UP000198211};
RA Ali S., Shao J., Larry D.J., Kronmiller B., Shen D., Strem M.D.,
RA Melnick R.L., Guiltinan M.J., Tyler B.M., Meinhardt L.W., Bailey B.A.;
RT "Phytopthora megakarya and P. palmivora, two closely related causual agents
RT of cacao black pod achieved similar genome size and gene model numbers by
RT different mechanisms.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-
CC phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004747}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ24602.1}.
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DR EMBL; NBNE01000007; OWZ24602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A225X4L3; -.
DR STRING; 4795.A0A225X4L3; -.
DR EnsemblProtists; OWZ24602; OWZ24602; PHMEG_000278.
DR OrthoDB; 54452at2759; -.
DR UniPathway; UPA00074; UER00130.
DR Proteomes; UP000198211; Unassembled WGS sequence.
DR GO; GO:0043727; F:5-amino-4-imidazole carboxylate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.1970; -; 1.
DR InterPro; IPR039476; P2CMN_synthase_LarB.
DR InterPro; IPR000031; PurE_dom.
DR NCBIfam; NF033503; LarB; 1.
DR PANTHER; PTHR43064; PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR43064:SF1; SLL1489 PROTEIN; 1.
DR Pfam; PF00731; AIRC; 1.
DR SMART; SM01001; AIRC; 1.
DR SUPFAM; SSF52255; N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE); 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000198211}.
FT DOMAIN 174..306
FT /note="PurE"
FT /evidence="ECO:0000259|SMART:SM01001"
FT REGION 330..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 70448 MW; A0B87DCEE400B4DA CRC64;
MNLVGVLRSR HARRFMAVAS GRGVATQFQA AGFTSSSNSE DSNSILELLQ RVADGKVSPQ
SAAELCAAAA EYEAVGNFAK IDTKREFRTG FPEVVYAESK TPEQVAAIMN AMIDGGENNV
MASRVTQQAA DEIRALMPHQ HLTYYEVPRI LASKTLDNPI KREPTKSDNA KKEASACVLC
AGTSDLPVAE EAAVTLELAD FRVTRLYDVG VAGIHRLLRN QHVLRASDVA ICVAGMDGAL
PGVVGGLTSS PVIAVPTSVG YGAAFGGLAP LLTMLNACSP GVGVVNIDNG FGAAVLAASR
NRRYVAPTST SSLSGELSPS SLHGSAAIKQ EPTAMDTESS SDSQLPSPAF RSLQRTLPIG
GESRERQQKN RRKRRSSGDD AVVREEAESS EEEKQEQVEM LTISVEELER RLTVVADEQL
KRIAEFGRVH GTIMQEAKEY VGNMEMQMRN QLEHERTVLR AEAEEFVAET TKENEALRQK
VKDLTLQVEG LEKQVDTLEQ ENDATKKAKA SSTQHEETQQ GNGEQPQQTH SPPNNQTQVL
PENGKTNRTV ETISANNSHK ANGSEPGGRK SLHPPLVIKQ VSTCSASIPT NPTPQHEGNE
SKDQLVQQQQ PPTPPNGTQP KARVVAQDGL STTKSSQPPA PSGPEGAGEI NTSGGTT
//
