ID A0A226BY08_9FIRM Unreviewed; 616 AA.
AC A0A226BY08;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=CDO51_06875 {ECO:0000313|EMBL:OWZ83811.1};
OS Natranaerobius trueperi.
OC Bacteria; Bacillota; Clostridia; Natranaerobiales; Natranaerobiaceae;
OC Natranaerobius.
OX NCBI_TaxID=759412 {ECO:0000313|EMBL:OWZ83811.1, ECO:0000313|Proteomes:UP000214588};
RN [1] {ECO:0000313|EMBL:OWZ83811.1, ECO:0000313|Proteomes:UP000214588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18760 {ECO:0000313|EMBL:OWZ83811.1,
RC ECO:0000313|Proteomes:UP000214588};
RA Zhao B.;
RT "Draft Genome Sequence of Natranaerobius trueperi halophilic,
RT alkalithermophilic bacteria from soda lakes.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ83811.1}.
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DR EMBL; NIQC01000012; OWZ83811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226BY08; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000214588; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000214588};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 12..90
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 200..235
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 251..493
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT COILED 192..223
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 616 AA; 70591 MW; 8AE1DECBE2325CE0 CRC64;
MSIEEKLKTI PTKPGVYLMK NDSGRVIYVG KAINLKNRVR SYFNASNQSV KVQVMVPKIK
DIETIVTDSE LEALILENNL IKKYRPKYNV SLKDDKNYPY LKITIEEDYP RLITARRMGK
KGRYFGPYPN AGAVRETIKL LRKLFPVRTC KGDKPKNIGK RPCLNYYIDR CLAPCNEKVT
ILEYDNMISQ IIAVLEGKEE DLLKELERKM NQAAEEMEFE KATEYRNQKT ALEKIRQKQK
IVSDRQEDYD IIALYTQEKE ACVQIFYIRG GKLMGRNNFK ISAGVEDGES DILTSFIKQY
YAQATIIPKQ ILVSPPIGEN DLISSWLTEK RGSNVEIRVP QRGEKYQLMN MALKNAKLEL
EQQVINSEKE KRMTEGALKE LALRLSLTEI PFRLEGYDIS HTQGESTVAS MVVFEGGSPK
NDDYRRFSIK TTSGPDDFKA MNEVIKRRFN RAKNEETDMQ SEGNEGSIKF AVLPDIIVID
GGKGQLNSAL RALKEVGYED IPVLSLAKQD EEVFVPGKSQ PMNFPMDSEA LKLLQRVRDE
AHRFAVTYHR KKRGKAMKKS VLDGIPEIGE RRKKELLQTF SSIDEIKNAD EKQLLELPSM
NKKAVQNLLV HLKKNM
//
