ID A0A226BYH0_9FIRM Unreviewed; 517 AA.
AC A0A226BYH0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN Name=cobA {ECO:0000313|EMBL:OWZ84088.1};
GN ORFNames=CDO51_05070 {ECO:0000313|EMBL:OWZ84088.1};
OS Natranaerobius trueperi.
OC Bacteria; Bacillota; Clostridia; Natranaerobiales; Natranaerobiaceae;
OC Natranaerobius.
OX NCBI_TaxID=759412 {ECO:0000313|EMBL:OWZ84088.1, ECO:0000313|Proteomes:UP000214588};
RN [1] {ECO:0000313|EMBL:OWZ84088.1, ECO:0000313|Proteomes:UP000214588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18760 {ECO:0000313|EMBL:OWZ84088.1,
RC ECO:0000313|Proteomes:UP000214588};
RA Zhao B.;
RT "Draft Genome Sequence of Natranaerobius trueperi halophilic,
RT alkalithermophilic bacteria from soda lakes.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWZ84088.1}.
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DR EMBL; NIQC01000008; OWZ84088.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226BYH0; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000214588; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000214588};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 13..224
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 275..501
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 517 AA; 57036 MW; 124C6A390B319D80 CRC64;
MILTPGGDDL NGKVYLVGAG PGDEGLITKK GIDCIKKADV IIYDRLISND ILTYANETTE
FIYVGKVPNN HTLTQEEINQ LLIEKAEAGY TVTRLKGGDP FVFGRGGEEA KALHDRKIKF
EIIPGVTSSI AAPSYAGIPV THRNVSSSFS VITGHENTDK PNSSLSWDKL ATATDTLCFL
MGIGNLENIV ENLIKHGRDP NTPVAIVRWG TFTDQYTLTG DLTNIVQKVK KHNVKSPGVI
VVGEVVNLRS SLNWFETKPL FGKKILVTRA RSQASELSRN IKELGGEPVE FPTIKVEPPT
SLDELDNAIN NLGDYHWLIF TSQNGVNFFF HRLFYHQLDV RSLANIKICA VGRKTRECLE
DKGLLVDVVP KEYRAEGLIE ALKGKVKKEE KVLFPRAKKA REILPKALKD MGLEVNVVPT
YQTVKESTAQ EEIKTLLQEN EIDAITFTSS STVENFVDLI GTEGLENVDT FSIGPITEKT
CNDLGIKVNA TSDEYTIEGL VDVLTRRLGG VFDSTLI
//
