ID   A0A226C3R1_9FIRM        Unreviewed;       452 AA.
AC   A0A226C3R1;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Sodium:alanine symporter family protein {ECO:0000313|EMBL:OWZ85060.1};
GN   ORFNames=CDO51_00825 {ECO:0000313|EMBL:OWZ85060.1};
OS   Natranaerobius trueperi.
OC   Bacteria; Bacillota; Clostridia; Natranaerobiales; Natranaerobiaceae;
OC   Natranaerobius.
OX   NCBI_TaxID=759412 {ECO:0000313|EMBL:OWZ85060.1, ECO:0000313|Proteomes:UP000214588};
RN   [1] {ECO:0000313|EMBL:OWZ85060.1, ECO:0000313|Proteomes:UP000214588}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18760 {ECO:0000313|EMBL:OWZ85060.1,
RC   ECO:0000313|Proteomes:UP000214588};
RA   Zhao B.;
RT   "Draft Genome Sequence of Natranaerobius trueperi halophilic,
RT   alkalithermophilic bacteria from soda lakes.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWZ85060.1}.
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DR   EMBL; NIQC01000001; OWZ85060.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A226C3R1; -.
DR   OrthoDB; 9804874at2; -.
DR   Proteomes; UP000214588; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000214588};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        102..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        151..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        216..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        243..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        310..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        355..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        394..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   452 AA;  47794 MW;  74CF8C2D0ADD1E53 CRC64;
     MGDMVLAFNE WLNELVWGPI FLTLLAGTGL YLTIRLGFFQ FTHFGASWKE TILSRIKKTE
     SEEGGAISGF QAISSAMAAT IGIGNIAGIA TALHLGGPGA LFWMWMTALV GMATKFGEAA
     LAVKFRERNG EDIAGGVMYY IQNGLGGNWK WLATIYSLFA GFAAFGIGNM VQSNTVAEQL
     SSDFAIPSLA TGLVAAALVG LVILGGIKRI AQVAEILVPL MTVIYIGGAL VILVLHIEEI
     PGAIGSVFHH AFNPASAAGG FGGAVVREAI RFGVARGVFS NEAGLGAASI VHAQASNSPA
     KQGMWGIWEV FIDTILVGTM TALTILVTGA LETGENAAAL TATAFDKGLP GPGGYFITIS
     IMVFAYTTMV TWSFYGEKSW EYIFGSKVRI PYRVVFVGLI ILGAVGALEA VWDFADTMNG
     LMAAPNLVAL IALTSVLVQE KNKYVRGEDE EY
//