ID A0A226D4C3_FOLCA Unreviewed; 1748 AA.
AC A0A226D4C3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Guanine nucleotide exchange factor DBS {ECO:0000313|EMBL:OXA40415.1};
GN ORFNames=Fcan01_24810 {ECO:0000313|EMBL:OXA40415.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA40415.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA40415.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA40415.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA40415.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA40415.1}.
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DR EMBL; LNIX01000033; OXA40415.1; -; Genomic_DNA.
DR STRING; 158441.A0A226D4C3; -.
DR OrthoDB; 4244290at2759; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11856; SH3_p47phox_like; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22826:SF201; LD43457P; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1146..1340
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1352..1463
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1600..1667
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1694..1748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1748 AA; 191922 MW; 8522AB3DA4D084B3 CRC64;
MANLFPHHQQ QHQQQQSSSV VEEEENCSHK PILLSDGLTE NIKTKQNHED STISGCAISS
NEPATAGIGR SPVFQDIGHG KLYNSPRTGQ QSATFGNNNS GRTSNFQFHQ IPLPHNKNSG
RNRGNVSSFL GGGGGGRSQE NSSNTTFLER FRSQTNICES ANSGQKLTRN GSSFSMTTTT
SPIDVFPPPP VSPCSVKSNQ NFGPHRGNGN GFRGVSYPST TSSSSAHSYR ENSAPPKPKK
WFSFTNLLNK QNLSSLLNIP KSRLSVSSTL NSVFVGGGNS PSPSGSESGG SNVFFGLSFG
SFDKGGGFQP SNNSTSSSSH QNQQQQQHLQ SPTHSGSGGI STGNDFSTGQ NQVIFRRKSG
GGGGARSERS SASTSSSVGP ISKHYSSGNA SYDSDRSSGG GYYTVNSGGC GGGPPSSSSG
SNRLSCGEFF TGTPNSPIFS GTERDPEFHQ WHQHHNLRDG GGGQSMSGFS SRNADYSSRD
FYHFHKSLGR SLPTLLESME SGIASQSSSE NGGGGGGPSS SHYSVDSVMD LMHQEFALLT
GAKSLDDHYI LTFPDRGNFH LLGDEDYRRL MIYLTAVPPM HDSESGFVII VDRRNDKWNS
VKTTLVRISN YFPGLIHRVF VLRPVGIFQK ALSEISSKLF RTENLRFRLT VCNSMADLFV
FVDPSQLTLD LGGLISYDKV KWVQQRVEVE AFHHALQSLS RDLKGFTEVF HDLEYPNNVG
STEVLISDKH SEFQRLRSDL TQAVDHGEHL LFRIKDMCNT PEPDNGMGSS NARKNGGGDI
VKNHKGKLGQ RSVNSSSVQL INVISVERYI IQIEETARLF EEFWIKEKTS LEQCLQLRRF
EHDFREMQAT FDIGMKRLEE LGEVGESLSA TEFLIRDTSE FEASSRDDVS RAQELERIGR
EIVASNQSAV DSVEPKCYEL SRIIAQFQII LEDKMTKQKE WREIQAVIEK ANQLCNEGMD
LMTCQISDQL TGGEDSTDCR DGGSSCGSAL ISKIDDFLER IRTMREELSC FKTTPTSPTT
SQSKPLVKQV LKRVEDVEVM CIKRKSVIVQ QLSKLTKTRR SSGSSFASTP SSGSQTSCYL
NNLELKSAKS TSQLDSGMAE DHYSSPTSLR SGSSTLSLDG SSGGYGNNSK HASNRPDGDW
ELKKIKRGHV LNELLQTERS YVEEIGEILA EYRDQISNPE ARSLLPAQLQ PIITPTKLQR
RNPSVAVLFC NLDEIHAFHA KSFLPDLSNC VESIELVGLC FIQRHSDFLS MYSQYCQLLP
ASEILRKDIG ENHPWFVACR NRLGHKLPLG AYLLKPVQRI TKYHLLLKDL IKSSEGCEGY
AELLEALECM LVVLRCVNDG MHQLGITGYP GKLIEEGYLL LQGSFLLWTD NKKDRLRLKG
HQRHLFLYQR SVLICKKVPK SSLYEFRNKL SLSEVGLTEA LKGSGASKKF EIWINGRQKV
YLLQAESAET KDIWVREIKK LLLEQLESIR ATKSQTIAAC AAGMSSSQSL GVSNLQPLAA
ARRQKMMSGK GITVNGWRTT NIGHRPLRQV SSWDNPDVVP RPKSRISNEC DIDEDLWSCS
EMSNSDDDDN STATPPSRPL SIGDESAVAM NVYGVGENVE NSPRYVVLAD YGPMGPAEVL
LKEGDIVSLV KVGCGGWWFV KILHSTASAI GPMEGWAPAA YLEKFNSPGI TKRKTGSVTD
ISGGNVLSVS SKPNQIMMKN KDSNQQGIGG RSASIPTGGS SSSRLCSTSS TSRQKLSQST
EDILSALR
//
