ID A0A226D802_FOLCA Unreviewed; 1037 AA.
AC A0A226D802;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Erythronolide synthase, modules 1 and 2 {ECO:0000313|EMBL:OXA40984.1};
GN ORFNames=Fcan01_24364 {ECO:0000313|EMBL:OXA40984.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA40984.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA40984.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA40984.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA40984.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA40984.1}.
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DR EMBL; LNIX01000031; OXA40984.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226D802; -.
DR STRING; 158441.A0A226D802; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000198287}.
FT DOMAIN 110..529
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 90..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 113916 MW; 90155AB68BF0CE5D CRC64;
MMNGTKERTS IWVGAIRKVQ EIPWLVETYR KEETAHNNSA VFVGPAISLQ ECTKLEMIFD
FVVTMGEDEN PQDCSFRLWD TVTFRIAHDG EVPNGMTTSD EESTDQTSEN EPIAIIGMAC
RLPGSNDYHT FWNNLVGGVD SIGEAPKDRF QPERGCVKMT SEHLSTEARY LSCPVDTFDA
KFWGISPLEL EYTDPQARMV LQLAWEALED AGIPPSTIHG TDASVLLGFW REDYNDLLVQ
TGSSAGNELR RYLGCSMGTA AARVAHAFGT TGPALSTETG CSSRVCSIGA AMAALRNNKT
GLALAGGANL ILKPFLYKEF QGVLSPSGRS KVFHSDADGS ARAEGVIMYA LKREADARRD
GDHIYALLSG YGTSQEGLSR SAGTLTIDGE ARAITLALMD ACVSPSDIDW LEMHGTGTKV
GDPIEVAATR VAYGLDIKKS ERRRPLIITS VKANIGHTES VSGAAGLLKV VLGMKYGAIP
PQRLNGTLNP KFNLEGIQIP LQLLPWKGKY AGVSSFGITG TNSHLIVQRV SIPRNNKIPQ
SDTLSAYILP LAAKCASSMA ELKKRHVFAL QNLDDRQLAD YCYTSAVCRD HFKEYRYAVV
GRNKMELIQA ILSDHAQEPQ LKPHKPYENS NSKVCFVFPG QGCQYAVEKN YGINLKSKIF
EGTGTSIYSQ LCIFAVEYCI IKVWGAWGIF PSIVLGHSFG EFAASVVAGT LSLPTALELL
VASRTKMVGT HDEDIAALSS CEQTVISSKP DTISKFSMFC TKFGIKNTAL HVTHAFHSRA
LELVLNQFES EAAQLNYPSR KFKSVAYVSS VYGRVVDHDE KLEANYWRKH MRQRVEFIRA
AKAALQEQNG QIFLEVGPHP VLCPLVSKIA ASGIITATEK PLFFPSLRKG TEDMLTMLDT
ATLLCTEGVD LDWSTLWKSL TLAPLCKVPS LVPLYAFTSN ESFWFSTIPS EKPASFYEEQ
EVHPLLGSCF PTMVEGSYAF VNSTRRLLAN PLSGDWLQDH RLGSHIIFPA AGYAEMVFAA
VDIIKRRSNE NCATIWN
//
