ID A0A226DA19_FOLCA Unreviewed; 1552 AA.
AC A0A226DA19;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=Fcan01_23945 {ECO:0000313|EMBL:OXA41096.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA41096.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA41096.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA41096.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA41096.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA41096.1}.
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DR EMBL; LNIX01000030; OXA41096.1; -; Genomic_DNA.
DR OMA; QSMDTQR; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR45786:SF82; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044, ECO:0000313|EMBL:OXA41096.1};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287}.
FT DOMAIN 450..630
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT DOMAIN 1371..1417
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 176860 MW; F152D4329D976F3D CRC64;
MGPKRQQTDE ERNLQQVEAK RRRAEAQRLR RANLTDEQRN QHREQNSQTK RNRIANMSDE
ERNLHRKQNA QSERNRVANM SDEQRRQRRE NDAQNTRNTR QNMTAEQTSL YQNVHNMRLS
TSRTRVRQRS LAATIATALT DNFDETTIPL HSCGQLNSVC QFCQAKHFAS ERPTDGYFNI
CCNKGKVFLT QIRQSEFLKD LLTNNHEHSK NFMENIRSFN SSLAFASMGA NIAPPPGYGP
YAFRIHGQIY HRAGALNPCN GGQRKFAQLY ILDPYEASEQ RLRMSENSKC NPDLMNELSQ
FMTQQNPFAD ACKMLHEVEQ ESIADAQLHG VEPSTVSMAI IQDRNSDLRR YNAPRTNEVA
VIFQNGNGDP PLERDLIIHC RVTADNPDQR ACQRINILDP NLEPMTYPLL FPYGDQSWGL
NIRLQDRPGV LRNRPQSANP RQNVTQMQFY AYRFAIRDAF NPFLSAGKLT QQYIVDAYVK
TEANRLNYLR QNQKALMAES YQGLIDHIGS VAEQQGLNPG KPVILPSSCQ GSPRNMTQNY
LDAMAIVREY GTPDLFITMT CNPKWNEITE NLGPGQSAEF RPDLVARVFK IKLKELLSDI
CDKHVLGIPI AHVHVIEFQK RGLPHAHMLI ILKKEFKPSD CDKIDKLVCA EIPNIETNPR
LHEIVTKHMI HGPCGVHNLN SPCMDSLTNE CTKKFPKAFQ NATVIEGNKG YPLYRRRNNG
ISVMIKNKRI DNRWIVPYNP SLSLKYNCHL NVEVCASIKS VKYLFKYVYK GHDCANVTIR
EETTLHHYEI QTYMDSRYVS APEGAWRLFG FEMHKQSHTI IRLAVHLPGN QSIVFNPNDV
AQAVANNEHR HTTFTAWFAL NSTLPSDEHC LYADTPKKYW FPPNLRVWQK RKQEKRGEKV
IGRMYTVSLQ DHPESYYLRL MLLHVKGATS FENLRTFNGV RCDTFLEASK RMGLLSNDET
WDNTMADAVI SSMPRQLREL FATICVFACP PNILQLWDKY KEYLIEDYSR HPNHDADCIQ
CENLALRDIQ DIFIIHGKSC NEFGLRTPPT NIPRNIDDYF DVEAERERGA EMYETLNDEQ
KAAFNTIIES INCNIPQSRC FFLDGPGGSG KTYLYKTLLS TVRGMGEVAL PVASTGIAAN
LLKGGRTYHS QFKLKVPLDE TCTSSIRQTS SEAELIRRAK LIIWDEATMA PSIALDAVDR
CLKHLMENNL PFGGKVLLLG GDFRQTLPVV PHASRAAIVE SSVKFNKYWE HFKILKLHNN
VRSEDPEFSK WLIDLGNGSL PTTEVLPDDV IEIPENMIRT DSIVEEIFGK KLTVQDVHKF
SKMAILCPKN VDVDKINEDV LDILEGEKVT YLSSDSIVDE TDVDRQNYPI EFLHDQTSSG
MAPHKLNLKI GAIVMLLRNL NTKHGLCNGT RLIVKELKPN LIIAEVLTGP AQGNIVFIPR
IDLTPSNPDL PFTLKRRQFP IKLAFAMTIN KSQGQTLDKV GVYLPDPVFS HGQLYVALSR
AKRSCDVKMK IVDGPLQACG GSDKCTVSTF KNEKVRGQHT EGGPRPLPWV DK
//
