ID A0A226DDN5_FOLCA Unreviewed; 715 AA.
AC A0A226DDN5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vascular endothelial growth factor receptor 1 {ECO:0000313|EMBL:OXA43078.1};
DE Flags: Fragment;
GN ORFNames=Fcan01_21911 {ECO:0000313|EMBL:OXA43078.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA43078.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA43078.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA43078.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA43078.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA43078.1}.
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DR EMBL; LNIX01000023; OXA43078.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226DDN5; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProt.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 1.10.530.10; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF617; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00062; Lys; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00409; IG; 2.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:OXA43078.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 17..100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 356..459
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 398..708
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 106..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 569
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 574
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 587
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OXA43078.1"
SQ SEQUENCE 715 AA; 81405 MW; E75C790230ECF27F CRC64;
DITFSSIGGT IVLEESGSET ILAENKLNCS AKGYPIPNLS WEWDGQDSDT HIEQSFITED
IEKFAILTFT SISESDRKTY ICHAENMYER ESQIFEVEVI LEDISTTELM EDTTIEPTTE
DTTTEPTTED TTTEPTTEDT TTEPTTEDTT TEKITEPDSS TTELTDSTDQ GTTPRSSSST
TERTSTTIDT STSYSTTKFP TTLISTTPFL PTTTWATTTL NPPGSGKVYT ICELAEELTY
MFQDVYDWNV DIEKWLCLAK ITTSFNASHV EYSPSDSLVY YGIFKISNRW CHDRYNTENP
CSLSCNELLE GNLLNSVMCS SLIYNQTGYN FDEWPEYDPN CALYTEDYTN ICAQSPFFVF
SGDAETEKVF EEYSQMKNIT CSAQGFPPPI LTWDYATQDY IIKSNSRLFS NVTRFTDADG
NWTISTTLYF RVVERSDDRV YICDASNIAG SANRTYTVSV ISESTDWKLT LLISGGSTLS
LYIKDYLPFH SLTFYTDFRR SRGSLEGILR AKRNALYRSN YFNPMYTIPG YLGASTFVKN
FSTSELLTFC RQVCSAMEYL GSRRIIHGDL SSRNVLIDAN GTAKISDFGL SRQIYGNYKE
YFVASKETAI PWRWLAIETL ENLRFSTDSD IWAFGVFMWE VFSLGDVPYS AGITWSPEFV
KYLKSGFRLQ VPKFATDEIY NVMKMCWEQE PSERIRFRSI NSKLDDLLQL EYSKK
//
