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Database: UniProt
Entry: A0A226DFK8_FOLCA
LinkDB: A0A226DFK8_FOLCA
Original site: A0A226DFK8_FOLCA 
ID   A0A226DFK8_FOLCA        Unreviewed;       614 AA.
AC   A0A226DFK8;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Malate synthase {ECO:0000256|ARBA:ARBA00012636, ECO:0000256|RuleBase:RU000555};
DE            EC=2.3.3.9 {ECO:0000256|ARBA:ARBA00012636, ECO:0000256|RuleBase:RU000555};
GN   ORFNames=Fcan01_21530 {ECO:0000313|EMBL:OXA43644.1};
OS   Folsomia candida (Springtail).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC   Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX   NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA43644.1, ECO:0000313|Proteomes:UP000198287};
RN   [1] {ECO:0000313|EMBL:OXA43644.1, ECO:0000313|Proteomes:UP000198287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VU population {ECO:0000313|EMBL:OXA43644.1,
RC   ECO:0000313|Proteomes:UP000198287};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OXA43644.1};
RA   Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT   "The genome of Folsomia candida.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+);
CC         Xref=Rhea:RHEA:18181, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15589, ChEBI:CHEBI:36655, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00001699,
CC         ECO:0000256|RuleBase:RU000555};
CC   -!- PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from
CC       isocitrate: step 2/2. {ECO:0000256|RuleBase:RU000555}.
CC   -!- SIMILARITY: Belongs to the malate synthase family.
CC       {ECO:0000256|ARBA:ARBA00006394, ECO:0000256|RuleBase:RU000555}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXA43644.1}.
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DR   EMBL; LNIX01000021; OXA43644.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A226DFK8; -.
DR   STRING; 158441.A0A226DFK8; -.
DR   OMA; ADCYMAD; -.
DR   OrthoDB; 177378at2759; -.
DR   UniPathway; UPA00703; UER00720.
DR   Proteomes; UP000198287; Unassembled WGS sequence.
DR   GO; GO:0004474; F:malate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   CDD; cd00727; malate_synt_A; 1.
DR   Gene3D; 3.20.20.360; Malate synthase, domain 3; 1.
DR   Gene3D; 1.20.1220.12; Malate synthase, domain III; 1.
DR   InterPro; IPR044856; Malate_synth_C_sf.
DR   InterPro; IPR011076; Malate_synth_sf.
DR   InterPro; IPR006252; Malate_synthA.
DR   InterPro; IPR019830; Malate_synthase_CS.
DR   InterPro; IPR001465; Malate_synthase_TIM.
DR   InterPro; IPR048355; MS_C.
DR   InterPro; IPR048356; MS_N.
DR   InterPro; IPR046363; MS_N_TIM-barrel_dom.
DR   NCBIfam; TIGR01344; malate_syn_A; 1.
DR   PANTHER; PTHR42902; MALATE SYNTHASE; 1.
DR   PANTHER; PTHR42902:SF1; MALATE SYNTHASE 1-RELATED; 1.
DR   Pfam; PF20659; MS_C; 1.
DR   Pfam; PF20656; MS_N; 1.
DR   Pfam; PF01274; MS_TIM-barrel; 1.
DR   SUPFAM; SSF51645; Malate synthase G; 1.
DR   PROSITE; PS00510; MALATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435,
KW   ECO:0000256|RuleBase:RU000555};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000555};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW   ECO:0000256|RuleBase:RU000555}.
FT   DOMAIN          86..146
FT                   /note="Malate synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20656"
FT   DOMAIN          238..489
FT                   /note="Malate synthase TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01274"
FT   DOMAIN          497..613
FT                   /note="Malate synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20659"
FT   ACT_SITE        242
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601465-50"
FT   ACT_SITE        532
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601465-50"
SQ   SEQUENCE   614 AA;  69043 MW;  9D62AFB39A559EDB CRC64;
     MLIKIILRPL HPQGGSLTRS TTSSRCFSNS APAQNSNKNL TIFGKSKSFL SPRAVLGASS
     YQVFKKQRST MAQIDLAVNT QSGCLEFVIP PDSSTKEILS NDALVFLKKL HRNFEPRRKE
     ILEARVRRQQ AINEGKDVLD FLPSTKFIRD DPTWHISPLP PQLHRRRVEI TGPVDRKMVI
     NALNSGADCY MADFEDSTAP TWQNQIAGQA NLKDAIRRRI DFTAPNGKEY KLEDEVATLL
     VRPRGWHLDE KHLLIDGERL SGSIFDFGLY FFHNAQELLA RGMGPYFYLP KLQSHLEARL
     WNDVFVFAQD ELGIPQGTIK ATVLIETIMA AFEMDEILYE LKNHSSGLNA GRWDYIFSCI
     KTFQKKSPQT INGPFAFPDR SQITMNVPFM RAYCLSLVQT CHRRHAPAIG GMSALIPIKD
     DSAANEKAMS AIRDDKIRDA KDGFDGGWVA HPGLVNLAMA EFVKVLGDNS NQIKKPLLLD
     YVPKAENILN FQPTEPKITE TGLRSNVRVG IQYLASWLAG VGCVPINNLM EDAATAEISR
     SQIWQWIHSS KGVLDDGRKV NDALVDAITA DELTKLKKNF PNVKTFDKAA DIFIRLSKSP
     NFEEFLTLPL YETF
//
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