ID A0A226DFQ1_FOLCA Unreviewed; 807 AA.
AC A0A226DFQ1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=AFG3-like protein 2 {ECO:0000313|EMBL:OXA43808.1};
GN ORFNames=Fcan01_21407 {ECO:0000313|EMBL:OXA43808.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA43808.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA43808.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA43808.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA43808.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA43808.1}.
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DR EMBL; LNIX01000021; OXA43808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226DFQ1; -.
DR STRING; 158441.A0A226DFQ1; -.
DR OMA; ARQKGNF; -.
DR OrthoDB; 9585at2759; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF2; SD01613P; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..488
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 55..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 88671 MW; 0FFAC6E4DB39F8EE CRC64;
MMAHRFVLTP CRQLDRVLRR SLITGDASHI YRRFPEIHRI LSQVRVYFGD KPPPKGFEKF
FRPSKSGDKA PPSKSGDGKE AGTKKSGENA PPPPPSRAAS SSGPTNTPPP SSARPPGDPW
SSFLGGGGPR GGSTGGGKQG GLGSEGGDKM IFLSVVATIG LLGTFAYYEM SYKEITWKDF
VNNFMARNIV EKLEVVNKKW VRVRLNPGQN VDGSSILWFN IGSVDSFERN LENAQMEMGI
EGSNFIPVIY KTEIEAASLT GVLPTILIIG FLLYMMRRSA EMMGGAGRGG RRGGIFGSVM
ESTAKLINSS DIGVRFKDVA GCEEAKVEIM EFVNFLKNPN QYYELGAKIP KGAILTGPPG
TGKTLLAKAT AGEANVPFIT VSGSEFLEMF VGVGPSRVRD MFAMARKHAP CILFIDEIDA
VGRKRGGRSF GGHSEQENTL NQLLVEMDGF NTTTNVVVMA ATNRIDILDS ALLRPGRFDR
QIFVPAPDIK GRASIFKVHL KPLKSELDKN DLSRKMAALT PGFTGADISN VCNEAALIAA
RDMNTTISLK HFEQAIERVV AGMEKKTNVL QPDEKKTVAY HEAGHAVAGW FLKHADPLLK
VSIIPRGKGL GYAQYLPKEQ YLYTKEQLFD RMCMTLGGRV SEQIFFGRIT TGAQDDLKKV
TQSAYAQIVH YGMNDKVGNV SFDMPQPGEM VMDKPYSEET AQLIDTEVRV LISTAYEYTH
KLLTEHKQDV LKVAERLLKQ EILSRDDMIE LLGKRPFPEK STYEEFVEGT GSFEENTELP
EGLKEWNKAR PEEKGTPPPQ AATPAST
//
