ID A0A226DMK4_FOLCA Unreviewed; 921 AA.
AC A0A226DMK4;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Protein kinase C-binding protein NELL2 {ECO:0000313|EMBL:OXA45841.1};
GN ORFNames=Fcan01_19746 {ECO:0000313|EMBL:OXA45841.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA45841.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA45841.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA45841.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA45841.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA45841.1}.
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DR EMBL; LNIX01000017; OXA45841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226DMK4; -.
DR STRING; 158441.A0A226DMK4; -.
DR OMA; TCGQFLE; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042:SF5; EGF_CA DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Kinase {ECO:0000313|EMBL:OXA45841.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:OXA45841.1}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..921
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013234399"
FT DOMAIN 277..334
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 335..403
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 404..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 446..487
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 488..526
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 528..559
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 635..670
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 754..813
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 568..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 531..541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 549..558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 921 AA; 100797 MW; C82088B7242C62A0 CRC64;
MFCIALVLLL QCLFGSCGYT FKGETLSVGG QEFVQVDLFD SLHLHNSTYQ GVKLGKGVRS
LGPGVVFSGD FRDVIISSEW VDRIRGHLEE VNDFTISASV KQNPNNVGTL LAFSRGLISA
LEIQSSGRKN ELRVISNSIV EAFPFRLADG SWHRLAISFS ASQVEILVDC RVVYRRVLRF
DPASMIHNSQ NISVWIGQKA PSNFLYQGVM QDLRLTFGPY GYLSQCPQVD TQCPTCSEYN
ALKMSFASLQ SQIEMLTARL SVAEARLTNV EQCECKKSCK VNATSVVGDG SKWLQDCQEC
SCKKGEILCQ HIQCPAINCT KPVTAPGECC PTCLETCYFR GRTYDHGEIE SGINIPMPEC
TDCECIHGSM KCNKHDPDKI CPPLSCPLSE QIVVPEKCCK VCPGTDYCAT HKNQCHPNAT
CVNLQTTFTC QCNEGYSGDG LKSCQDLDEC LLKRSHCARD SVCVNLDGSY DCKCIDGFRK
LNKFQCEDAD ECADGSHKCH KQATCTNTRG SYVCTCNSQY EGNGFQCSPV CNRTCENGGF
CIAPNVCSCR SGWTGDLCQM DVDECSSSSS SLPTGNQNIN NNNNGNNQTM SGDSAEGAVC
PKFAICVNKP GWHLCQCKEG YQLVLNQNGD AHCQDVNECE EDNVCSDGLT CINVEGTYEC
RCEEGNPQCS AGCIENDTVH QLGSKWMSED CHVCTCVSPG TTSCVSDTSE FCSQHCSLKS
GISSSTTTGG GHQCCSNCNN LNATLRYESH TKLKSCRHQV YSEIEYQSGD VWYSNCQTCE
CLNGETDCWS IDCPPANCHN AYLQPGDCCY RCPGEERNQD KCTHSHRNGT FSECHLLEET
IQSGTRVTLP QNNCISCKCQ DGELCCSYDY DCVHKSETAF LTPSSNLRVT TTTTKTTTTG
DSTTVSSITL GGSGNSSSRR L
//
