ID   A0A226DXQ4_FOLCA        Unreviewed;       985 AA.
AC   A0A226DXQ4;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Carotenoid isomerooxygenase {ECO:0000313|EMBL:OXA50242.1};
GN   ORFNames=Fcan01_14932 {ECO:0000313|EMBL:OXA50242.1};
OS   Folsomia candida (Springtail).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC   Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX   NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA50242.1, ECO:0000313|Proteomes:UP000198287};
RN   [1] {ECO:0000313|EMBL:OXA50242.1, ECO:0000313|Proteomes:UP000198287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VU population {ECO:0000313|EMBL:OXA50242.1,
RC   ECO:0000313|Proteomes:UP000198287};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OXA50242.1};
RA   Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT   "The genome of Folsomia candida.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006787}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXA50242.1}.
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DR   EMBL; LNIX01000009; OXA50242.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A226DXQ4; -.
DR   Proteomes; UP000198287; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR   PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR604294-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198287}.
FT   REGION          136..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..985
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..623
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         535
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         669
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         742
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         953
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ   SEQUENCE   985 AA;  108573 MW;  0F4BE93B625690CD CRC64;
     MDTRDYDGNK QHQQQGAVVT KMQNTDLSVW LRSCMKEAKE PVEGVVASEF PEEQTVEAVP
     AIWLTSDKTG CRWPNKVTPS FTNKKKDKNS SPGDGWTVYK CRVLGEFDNY TSANAAAHKA
     EDTSEIEVSK VDFSAGKRTR RTTQRPARSS SSDCEDLDKP SQANLTTTIP QIPVSVCEPY
     NNFIGGAVNE PGAAGSSQSL SSLAEDERNQ LNFQTVEILP NSQTFFIDSS GVLCTSGPTK
     NVGTSKSSNS GFSEGFQGVI IRALARIEAN QRDFRQILDE LVLNQRSGAT PHVEVDYSSL
     PKFPIESEAD LTAFDVQLSI DTERKVFEQY LVGIGGTTLP ITITEILERI FAKTLRIGLT
     YTGKGDGKKS YISFSNINTA IVGKIPIWVC GSLIQNGPGG VDIYGEHSCK HLYDGPGLLQ
     KFFVNNGTAT YTSKFIESHA FTQNIAAQKL VLSEFGTVAS PDPCQTIFAR IAAVFLGPVE
     LTTSDNANIS IHPFGNDIYA LSEFPFAHKI DVNNLETTKT INVHEQIGVI NHSPHPQIWG
     RKMYNIGQKL SLWHGPHYVI VELDTGRGAG GNKLNKNRRP SGSPQHTIYR SRSPSVVTNT
     NTSAASSVAS STTNLTNLAT PPQDNDVPDF DKPSSTPSKH PRPKSNPWAH AKIVASIPSR
     WPLSLCYMHS FSITNNYFVL IEQPLALFLP TVPLTQIAGS KPLASCLKFY KEEDTLFHVI
     SRHGRGNKLK KSFRSNSFFY QHTINAFETR DSESRETFLV VDVCMYSDPS LIDCMYVDTL
     KHAPCNPDYA KMFRGRAKRF LLKLGLDYDK HHKRKTASAS GGLLEVESEV IVDIGCEMPR
     INENFNGKPY NFFYAVSSDK DGDNPGTLIK VDVLRKTYDT WCEPNSYPSE PIFVQRPNSQ
     REDDGVVLST AVYGGESVTG PNKTSLLILN ATTWDLIAKI DFSVETAIPK CLHGWYFPCN
     DNDKDTPTTN SSSKGGGGGG TKHFH
//