ID A0A226E1M8_FOLCA Unreviewed; 4512 AA.
AC A0A226E1M8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Dynein beta chain, ciliary {ECO:0000313|EMBL:OXA51622.1};
GN ORFNames=Fcan01_13250 {ECO:0000313|EMBL:OXA51622.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA51622.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA51622.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA51622.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA51622.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA51622.1}.
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DR EMBL; LNIX01000007; OXA51622.1; -; Genomic_DNA.
DR STRING; 158441.A0A226E1M8; -.
DR OMA; ITMDAHG; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287}.
FT DOMAIN 213..786
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1295..1721
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1855..2181
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2339..2457
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2676..2770
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2818..3077
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3090..3436
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3463..3680
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3921..4041
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4073..4209
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4216..4510
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1655..1678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3315..3349
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4512 AA; 516244 MW; 6D33C6E1D355AFF7 CRC64;
MAKAGGGGNK DNTGGAYEPG ADPRLDFIFE YLTRSLKIKM DKWQKFVMTE DYRNVINDFF
DTPDFPMLVI NMNMGGQLIA SDAYPTSGKN KTCYFIKKEA GAIPLVKDDM SFKRNLIYGD
LSHQPLENLV TYIEHIISPL ITAEVNQEKW PDTVIADVKH HTQEICGVLY TIQGQLKGKT
LLPMPLNLDQ VDENDRKLAT GGPSDVDLQL KTNMETLVIK WSQQINDVLK QDSSKSLETG
NNPTPFVELS FWEERVQDLQ CIYDQLNEEK VRKIANILEQ TGSTYWPCFK SMFRNVVAAL
AEAQDILVHL KPLRKHLENV QNASFDEVLK HLGPMVHCVC LIWGHSKYYC SPARIIVLLQ
EICNLLIEMA RSHLGGSAVF QMEPEEGLVK CTAVVNTLQH FRDLYDAHKR ELPVYFRAEE
EAKNWDFLPH LVFKRFDKFF NRMKNLLVFF DTSVEFYKLE RIDIGGNKGK FLSARIHQVY
TKFMEFYQKF GGIQYDCSDP EDDSFLADEK LFEENVLDID QQLSAICTPT FDDCHTPESV
YKLILALGSL VERPLIKADI EPKYPQYVAM INKDLEQIKD QFDRTITPFQ ISQRPLANPV
LPPYSASIHW AREMRDRCDE NIEQFRSLEL HIEDQEVVGK LNNSYEELDE VFIKFQKETF
ESWTKSVERK GEGWMKQMLF SRDPEDKSLI VNFSSELYST MKEVKYMECA GFNDIPPLAQ
KLVDERTVFR KNLLFLDRIA YSYNKILNSS NPQERELLHS KMKEIDAKIQ TGSYKIRWSD
TDIWSYVDSL NDPVNDVEDR LGKSQENVNI IKKLVQTWLG HPLFERKDGN RKALLNMDEH
ANARKVKQYK EIEEMSVKVT EIVQLNKNLL TENTPDQKQP WDNYLQFLEN IVLDGLIKTV
AVSFGYLVDH TDGNLTPSPL FEVTMELNEN KVIFTPALDF SDPSSFLNLV EDILADISHQ
GTLVKRIRPG EDADYFTDVE KCPEISDMRS DIEQRVQTVM NQAFEYTLKF EPYTYLWEDD
RLEYLNQFLK YGHQLTPEEL EAKNSGEEEL QELVAPTLEQ FKQVIDKFEN LYIEVDNLPK
EHIFDKWFRL DMRPFRQSLL NKCKIWSLMF KQHMIDSVIG GLSGLEQFIT EAESGLTQPL
REGDLRKLIS VMTWLQQVKD RQATTDTMFE PIKKYIELLK MYDYDLPEAV FVQLEELPQK
WMNLKKLAIK IKHQVAPLQA QEVSSIRKRI TDFDVKQHAY RDVFKALAFF DKMSQFPYKE
LDDSHTDIAA LNTEYADICS AAELFEVHVP EPKSLRQCEK EVILTKNIWD YTYIVASLIE
EWKTTKWLNI NVENMDLECK RMAKEVKAMD KDAKAWEIFS LLEGVIRNMI SSLKSVAELQ
NQAIRERHWE ELMQATKVKF SMDESTTLAD LLVLNLHNFE EEVKNIVDKA VKENSMEKTL
KDFDGTWSAQ EYEFELHSRT GTQLIKASEE LIEILEDNQV QLQNIAMSKY IAFFHEEVEF
WQNRLFMADQ VLAVLGEVQR TWSHLESIFI VSEDIRKNLP EDAARFDKID RDFKNTLKKL
YKTKNVVEAT NQPGVLPDLE VLQKGLAICE KALADYLETK RLVFPRFYFV SSVDLLDILS
NGNEPEQVAR HLAKLFDAMA KLDFKKLEGA KIKPTKTQLE DGEEEKKDDE EKSTTATGMR
AKDGEAVPFN AVCECTGAVE TWLCRLEEAM RATVRNCFSE AVTTYEEKPR DSWIQDFPAQ
TALCGTQIWW TTEVNSALGK LEEGYENALK DYHRKQVNQL NTLIGLLIGQ LTSQERQKIM
TICTIDVHSR DVVLKLIAQK IETAQAFPWQ SQLRHRWDNL EGDCFANICD AQFKYWYEYL
GNTPRLVITP LTDRCYITLT QSLHLIMGGA PAGPAGTGKT ETTKDLGRAL GMMVYVFNCS
EQMDYRSIGN IYKGLAQTGA WGCFDEFNRI SVEVLSVVAV QVKSIQDGIR DKKTRFNFMG
EEIRLIPTVG IFITMNPGYA GRTELPENLK ALFRPCAMVV PDFELISEIM LVAEGFQSAR
LLARKFITLY TLCKELLSKQ DHYDWGLRAI KSVLVVAGSL KRSDPDRPED QVLMRALRDF
NVPKIVTDDV PVFMGLIGDL FPALDIPRKR DLDFEKNIRV ATLQLKLQPE DNYILKVVQL
QELIDVRHSV FIIGNAGTGK SQVWKTLYRA HQIMKHRPMY SDLNPKAVTN DELFGIINPA
TREWKDGIFS VIMRDQANLT GDGPKWIILD GDIDPMWIES LNTVMDDNKV LTLASNERIA
MTKMMRLVFE IWTLRVATPA TVSRAGILYL NPQDLGWQPY VASWIEKRDS SAEKANLTIL
FDKYVPTVIE MNKNRFKKIT PISEITHIEL LCNLLDCTIT GDTCPTDCPK EWYEVYFVFC
TIWAFGSATY QDQLLDHRVD FSKWFQNEFK FVKFPAGGTV FDFYIDMETK KFLPWTDLVP
RFELDPELPL QAALVHTAET TRVKYFLDML MARGHPVMLV GGAGTGKTVI INDKLAALSD
SYAIQNVPFN FYTTSEMLQR VMEKPLEKKA GRNYGPPGNK KLIYFIDDMN MPMVDAYGTV
QPHTLIRQHL DYGHWYDRIK LSLKDIHNVG YVSCMNPTAG SFTINPRLQR HFAVFSLSFP
GQEAVHFIYK TILQQHLASQ NHKFPLHVIR TCGSVVNAAL ALHSKVASTF LPTAIKFHYV
FNLRDLSNIF QGVLFSTIDC LQNPLDLVRL WLHEASRVYG DKLVDDKDIS TFAKMVNDNV
KKSFEDLEET SVLEKPLIYC HFAQGMEDPK YMPVKDYNFL QRLLIDALKS YNEFNSIMNL
VLFDDAVNYI CKISRILESP RGNALLVGVG GSGKQSLSRL AAFLSGLDVF QVALRKGYGV
QDLKNDLAIL YIKAGQKNMG TMFLMTDAQV AEEEFLVVIN DMLASGEIPD LLPDDEVENV
ISSMRTEVKT VGLEDTRENC WKFFIERVRK VLKCVLCFSP VGSTLRTRSR KFPAVVNCTS
IIWFQGWPEE ALMSVSQRFV KDIDVLPHDL HNPIASFMAY VHSSVTETSK TYLANEKRYN
YTTPKSFLEQ IDLYGKLVTT KNREAFAKAE RLESGLTKLE SCAQQVEGLK KVLAVQEVVL
KEKNEKADHL IQVVGAETAM VSSEKENAAK EEKKVAVTAT EVTKIKEVCR IELEKAEPAL
QAAYAALNTL NKANLTELKT FTAPPPDVIN VISAVYILWE GTRTGKVPKD KSWKAAKQGM
MGDIAKFLDG LMNLEKEKIT MTMVDAMKPY TDVAGFDPEN IKSKSFAAAG LCSYVVNVLL
FNDVFQEVAP KRRALQEATD ILNKALDRLK YLKHRITELE DKLTILTSEY DVAIAAKQKC
QTEADRTALT IDLANRLVGG LAAEKSRWIQ NAQNYRSSTI TIPGDMLLVT AFVSYLGCFA
KQYRVDLLDN TWIPYLRKLE PPIPMSASVD PLNILTDDAE IAQWNNFGLP SDRMSSENAS
ILMNSQRWPL MIDPQLQGIK WIKSMKAGNL KVIRLGQKGY LDIIEDAITK GVTILIENIM
ENVDPVLEPL LARNLIKKGT AIKMGDREID YNPAFRLILQ TKLANPHYKP EMQAQTTLIN
FTVTRDGLED QLLAEVVKVE RPDLEAQKSD LTKQQNEFKI LLKQLEDDLL TRLQSAKGNF
LDDTALVENL ETTKRTAQEV EVKAKEAVIT SRKIDAAREL YRPAACRASL LYFILNDLNK
INKIYQFSLK AFSTVFQNAI KTAPQAGDVA KRIDNLIDSI TYSVWVYTAR GLFECDKLIF
TTQMAFAIQL QRGAIHSKDL DFLLRFPIMP NVVSPLDFLN NTNWGAVKSL ASLDEYKNLD
RDIEGSAKRW KKVVESEYSE KEKLPQDWKN KQGVQRLCIM RALRPDRMTY AMTVFIEESL
GPKFVRSRRI DIAKSFEETS NTTPVFFILS PGVDPLKDVE ALGKKLGYTM DKGNFHNVSL
GQGQEIVAEN ALEIAGEKGH WVILQNIHLV ARWLATLEKK LEQNWERSHK KYRVFLSAEP
ASSAESHIIP QGILESSIKI TNEPPTGMLA NLHKALDNFT QDQLESCSKE LEFKAILFSL
CYFHAVVAER RKFGTQGWNR IYPFNTGDLT ISVNVLYNYL EANQKVPWED LRYLFGEIMY
GGHITDDWDR KLCRTYLEEY MVQELLDGEI NYAPGFPAPP STDYQGYHSY MDDVLPPESP
ILYGLHPNAE VGVLTATSEK LFKTIFELQP RDAGAAGSQS VTKEEKTKQI LDDILDKCPD
PFVMSEVVGR AEEKTPYVIV ALQECERMNT LIIELRRSLK ELDLGLKGEL TITLDMEDLG
NSLFLDQVPA SWAKKAYPST FGLGSWYADL ILRARELETW AIDFYLPAAV WLGGFFNPQS
FLTAIMQSTA RKQELPLDKM CLQCEVTKKI REEFTAPPRE GANVHGLFME GARWDIITGS
VAESKLKELY PSMPVVYLKS ITQDKADSRN MFECPVYKTR MRGPTYVWTF NLRSREKASR
WVLGGVALLL QV
//
