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Database: UniProt
Entry: A0A226E240_FOLCA
LinkDB: A0A226E240_FOLCA
Original site: A0A226E240_FOLCA 
ID   A0A226E240_FOLCA        Unreviewed;       366 AA.
AC   A0A226E240;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   16-OCT-2019, entry version 15.
DE   SubName: Full=Inward rectifier potassium channel irk-1 {ECO:0000313|EMBL:OXA51815.1};
GN   ORFNames=Fcan01_13603 {ECO:0000313|EMBL:OXA51815.1};
OS   Folsomia candida (Springtail).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC   Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX   NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA51815.1, ECO:0000313|Proteomes:UP000198287};
RN   [1] {ECO:0000313|EMBL:OXA51815.1, ECO:0000313|Proteomes:UP000198287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VU population {ECO:0000313|EMBL:OXA51815.1,
RC   ECO:0000313|Proteomes:UP000198287};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OXA51815.1};
RA   Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N.,
RA   Roelofs D.;
RT   "The genome of Folsomia candida.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OXA51815.1}.
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DR   EMBL; LNIX01000007; OXA51815.1; -; Genomic_DNA.
DR   OMA; KVHTRHQ; -.
DR   Proteomes; UP000198287; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198287};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:OXA51815.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     86    108       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       47    187       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      194    363       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     34       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        173    173       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   366 AA;  41398 MW;  A051B65900A374D6 CRC64;
     MGSEKLPIPN GSNINSSTRL SVISRSPSPS SYGSLSMAQQ QEYERTVTKD GVCNFTYSHV
     ARQRRKFFSD LFTTMLETKW RWTMSVFVLA YVGSWLLFAV AWFAIVYLHN DTVNVNNPDW
     RPCVSGIQNF TSAFLFSVET QHTTGYGFYH LTEDCPQAVI LFCTQSIFGV IIEGLLVGLI
     FTKMSRAKKR SQTLMFSTQA VISPRDGVLH FMFRIADMRT SHLLEAHVRA QMVQKRTTKE
     GEIISYHQEE LRVGGDGEMD DKILLFWPTT IVHRITPESP LYNLTPADLN ECNTSFEIIV
     VLEGIVESTG LTTQARSSYL PSEILWGHRF ECVASSKSSS GERIIDYSLF NSTVPCDPSE
     FSITTY
//
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