ID A0A226E8Y5_FOLCA Unreviewed; 988 AA.
AC A0A226E8Y5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Integrin alpha-PS1 {ECO:0000313|EMBL:OXA53096.1};
GN ORFNames=Fcan01_12231 {ECO:0000313|EMBL:OXA53096.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA53096.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA53096.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA53096.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA53096.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA53096.1}.
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DR EMBL; LNIX01000006; OXA53096.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226E8Y5; -.
DR STRING; 158441.A0A226E8Y5; -.
DR OMA; LHVSHDI; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 945..967
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 233..293
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 294..351
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 355..417
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 402..567
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 571..719
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 726..924
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 988 AA; 109691 MW; 398EA5D1FD42FC06 CRC64;
MKILVGAPLG QNLQQGTNRS GALFKCPLSG YEEDCEQVVT DGKREVDSSD LSPPLDDELK
DGQWLGVNVR SQGGKGKVVV CAHRYVHQGR DFRWGLGLCH FLTKDLEYDQ TLEPCRNKQR
RALEDYGFCQ AGTSADLLED DTALLGAPGA FTCRGMVYGI SVSDDYLNKD RNHYHTPVMD
NSTVDKYSYL GMSVAGAHFF GNNWTYVAGA PKAAMGSGQV IFFTKSTDSH MLKVEAELTG
EGFAFSYGNS LAVLDVNGDG KPDLVVGAPF YVDEKDSGGA AYVYLNNHGF RKNHPYVRLS
GPRESRFGIA LSTSGDLNKD GFEDLAVGAP YADEGYGSVY IFLGSKDGII KDPTQIIKAS
ESFPLVRTFG YSLSGGVDLD QNSYPDLLVG AFDTDVSILL RARPIIDIYT EVLGNLTNID
PNSPGCAAMP NADQPCFDLK ACFEIRGVTQ VRAASFQIEY KIEAETFLEG KKFSRVIFQR
GNTDRPQVVN QTITVRRSDV TNRHCSNEIV LLREGTRDIQ SPIAFKLTYT LMQREPEYHP
NSGVLPNIQN YPILNQQEAS KIILAHFEKD CGENDLCESD LFVKASTDLD TDNGGNYLLV
LGRNEVLGLN ISMGNFGEPA YEAMLYISHP KSMPYIGLME DQQKKGLGCT PFNGSLVICT
LGNPYKRQAT NLGDFQVMGL KFDAKNLKDI ETRLDFHVWA NSTSIETDDQ NDGVHLIVTV
IKMAELSIQG RVEPEKSFYG GTIVGESAIK SFAEIGPKIT HYYDIWNAGP WKASVFNVDI
WWPHQVENGK SQGKWLLYLE QPPVLDGDGH CVLPSNVTNV LHLRNKRETE TVIAPQKERD
VNGKIRTFVE MNCVRGSAKC FKIECTIRNL LPLESAVIKI HSRLWNSTLV EDYPTVDEVR
IRSRAVIRIS DEIEIRQDPG NDVAMAVATC YPDLKLKVEL EGIAWWIYAV SILAGIILLS
LIVYCLYRTG FFKRRRPVPT HTASVSRS
//
