ID A0A226EAH4_FOLCA Unreviewed; 1901 AA.
AC A0A226EAH4;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Polycystic kidney disease protein 1-like 3 {ECO:0000313|EMBL:OXA54087.1};
GN ORFNames=Fcan01_10350 {ECO:0000313|EMBL:OXA54087.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA54087.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA54087.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA54087.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA54087.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA54087.1}.
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DR EMBL; LNIX01000005; OXA54087.1; -; Genomic_DNA.
DR STRING; 158441.A0A226EAH4; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProt.
DR Gene3D; 1.10.530.10; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF600; PDGF-AND VEGF-RECEPTOR RELATED, ISOFORM J; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00062; Lys; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1901
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012443446"
FT TRANSMEM 1588..1612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1473..1577
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1685..1901
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 757..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1713
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1901 AA; 207937 MW; 38F38DAA0A861FB2 CRC64;
MQMINIFLLL GIFQIRSANS IRTGRSNMSI KGSNQIPALL NIEIGNILIP FSYCTTTVIK
RESVSIANIN FTAHPILIFT VLKEKKPWGT VIQNKFTLLP RRNLAPHCWA SLVILPNKNH
RKDFKPKYDS IRHLLIGKSW QEQYLIWSTA AILQTRKEVL TTWSKLKTYF ALREIILVDL
ATILDSEESI HKDTIIMQYP NPFYLNWKEI TPEMDVSLGV ASFNISCLMN HAFHCYQQLA
KISIIVADLN KYFWKTEFKP GTEKLTGNKN VSKMCSSPHA NFFDPIVCAA SLHEILVSWI
FHEIPKTTNI PPRFIFKSFQ HMSHLPYQGM SFVLHRIEGY NFISCYKVWQ DSSALNALTS
PFDMKSWMCM AGSALIVTLL LNASLGKQFY STSFLLTVGI LLESSVLEFL KSPRKFKTSL
IIGIWTVFSG TVLTSWYKTA FTMEMFAPVT HTAPWEGLLS IDGIKVLMPM NLFPSRLKGV
NLPAHIQRAV FFMEIHDRAV TILNYSSRTE RFRNYRKMAR LLINLIFPKS LGNIYNYIYN
IYNIILVGNL STCRKVALID RRDRIDAILP FLNDNREGIT YLVGEDDFFT TILGWPVPSV
RRNFAMRRLT VMISSGIYYH WKSLFKMIKP RKLFHHYSNW TYPKVERVTK LDFNSKIMTA
FYICGMFLVF CGDDDHLITN TTHPRDEDVM EIKFVATLTF SEVKLSHNST YTCYAKKDDP
TGITPIPYNF YVIVTQAPAT TDVTNHDGQL ELSDFQCTTT TESSSSPTST LPPTTGSSSS
PTSTLPPTTG SSTFPISTIP TTGSPTSPTS SLSPTTESSS SPTSSIPTPE SSSSPTSSTQ
PTTEGSSSAT STIPITTERP SSPTSTIVTT TESSTSPSST LPTTESSDSP TSTIPATTES
SGSPTSSIQT TQSSGSATSS MQTTESPSST TSTTPATTES SGSPTSSIQT TESSGSPTSS
IQTTQSSGSP TSSLQTTESA GSTTSTTPAT TESSGSPTSS IQTTESSGSP TSSMQTTESP
SSTTSTTPAT TESSGSPNSS IQTTESSGSP TSSIQTTESS GSPTSSIQTT ESSGFPTSSI
QTTESPSSTT STTPATTESS GSPNSSIQTT ESSGFPISSI QTTESPGSPA STIVTTTESS
TCPSSTLPTT ESSSSPTSSI QTTKGSSSAT SIIPVTTESS SSPTSTIPTT TESSISPTST
TPAATESSGS PVSSIPTTTE VPTSPTSSLQ PTMESSNPVS SVPPTTEVSV SPTISIPTES
SNLPNSSLLP TIKSSDLSTP SLPTTISSSS LPTATDFSDL TQDTISPTLG STIETPIDPT
SGTSDKTTTI NPIDPTTPLD GEKIYSACEV AQQLTYLHED NINWGEHIED WLCLSYVTTR
FNGSYLAADP DHRGRFYYGI FKISNEWCMD DHNSDNPCNG ITCNDLFHNE FDLVNSVSCS
KYIFAQKSFT EWPEFVELCE HLDKNYLEFC SEPPFFISDG KDETNKFYKE FDQNKNITCS
AVGYPPPELS WDNATFMHIS NAMGRLEVST TAQQISDGNW TMQSTIIFNE IYINDDGEYF
CVAENSVGSK TLRYSVTVIS SEPSLKQALI LGASFTLGLL GLLAVPTTYL IYTMRAKRNL
MLRELYQQFK YGQASTEATN STDLISTLNP EASSYLSRSE YVTYQEAINL PLPKELEILP
HRLKIMESAV LGSGAFGVVS QGRLDNKVTI AVKTVPKNAD ESKLIALLSE VKIMSFVGPH
PNIVQLLGVQ YIDLKKGIVY VAVEFCSHGS LEGLLHTKRR QLAMAQSYHE TMYNIPGYIG
LRHVEKPFEL HKLLTFSHQV CCAMEFLASK RIIHGDLAAR NVLLDSNLNA KISDFGLSKQ
MHDTYKKYIM GTKATACPCQ QSKIIRDQDT NHQQFAHAPG S
//
