ID A0A226EFK5_FOLCA Unreviewed; 792 AA.
AC A0A226EFK5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 03-MAY-2023, entry version 23.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN ORFNames=Fcan01_09949 {ECO:0000313|EMBL:OXA56365.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA56365.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA56365.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA56365.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA56365.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA56365.1}.
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DR EMBL; LNIX01000004; OXA56365.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226EFK5; -.
DR STRING; 158441.A0A226EFK5; -.
DR OMA; AFWCSIC; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR CDD; cd10985; MH2_SMAD_2_3; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF25; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 11..134
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 599..792
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 207..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 85483 MW; 19C32934CBB8C3E2 CRC64;
MTSILPFNHS PVVKRLLGWK KGEGEEKWSE KAVKSLVKKL KKSGGLEELE KAISTQSPGT
KCITIARSLD GRLQVSHRKG LPHVIYCRLW RWPDLQSHHE LKSIETCVYA FHAKLEDVCI
NPYHYQKVEN PVLPPIMVPR GSGSLGSGLS TSSTTLTSIG SISSVSPLTT TTTTNANSTS
SSNSNNIISS NSNLIFIANA NSSSSSSSTC ATKTSTNSNS TPAATISSSS TTTTTTPSPT
TPTTTTVNAN IRTATNANLM MMAMTNKNCP LNVELLPEPA DESSSSLVLS LSSLSNNSHS
DFHPDTVTTN NYCTSTSTTT SATNLGTIYS FSTSTTTTDN NPTFSSSTST TAATFGLDKL
QPFLLSALGN RNHQEEPLPE ILDNSNIISG QQHPPRSRFI IIKNIVNFES NTPEGQKRCR
YLAPVELLGV DQNRNQSVLV VEPRIVPPPQ QNGQSQIVGG GSGGALINIS NNSPILSINN
NNHLHRSPSS ASAASSPASI SSVASPTNIT SNGHANGIVE EFPSLEELGN TITDNSSFPT
NFDLNGFPPV TETPPPGYSS AMSEEGDTQD QGDLMGLSRF TPSPSMDAQP VMYCEPAFWC
SICYYELGTR VGETFHASQP SIVVDGFTDP SNSERFCLGL LSNVNRNVVV EQTRRHIGKG
VRLYYIGGEV FAECLSDSAI FVQSPNCNQR YGWHPATVCK IPPGCNLKIF NNQEFAALLS
QSVSQGFEAV FQLTRMCTIR MSFVKGWGAE YRRQTVTSTP CWIELHLNGP LQWLDRVLTQ
MGSPRLPCSS MS
//
