ID A0A226EGE1_FOLCA Unreviewed; 3042 AA.
AC A0A226EGE1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=Fcan01_07178 {ECO:0000313|EMBL:OXA56733.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA56733.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA56733.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA56733.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA56733.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA56733.1}.
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DR EMBL; LNIX01000003; OXA56733.1; -; Genomic_DNA.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51125; NHL; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:OXA56733.1};
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Nucleotide-binding {ECO:0000313|EMBL:OXA56733.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 129..150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 171..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 329..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 375..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1534..1555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1576..1598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1618..1637
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1649..1666
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1672..1696
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 1717..1741
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 2218..2237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 2433..2459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 2471..2492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 2504..2522
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 2534..2554
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 2621..2643
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 634..699
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 752..810
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REPEAT 933..974
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT DOMAIN 1839..2067
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2692..2922
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3042 AA; 340684 MW; 4A2EC36F8C86BBD0 CRC64;
MKKDNRKVSE NVLKPHARTS ERLSSSPTTG KVSSSFSSST DRNSKKLSEY AVNVVNLPED
EWQINSKDEN LEFFKKGRDY QPRKQKHHFT EEEKGIMATF ESAPLKPSHT AVFRHWLASL
PPRSDSESWL IIGLIAIIIG VLTFVMKMIC EKFQIFYNPF MKNFVERGRA FRLWVYFTGI
SCTCGALSAI VVVYLCPHAG GSGIHIGLAK KIFILRNPQA LEMGIVALAK NIKKSVDIEI
AKNAAGVASA FSSPITGLCF AMEEMSTHWS TGLTWQTFVC CILARSTTEL LHSVTGTIEQ
QIEHGRQFGI FELGESALFD MKVNLKLNLV VFIPAVIIGV LGGLLGSLYI FMYLKMAKAR
RRLIHKIKRP EVTNAFKVIE VVILCFICSS IIMMSMPMFY CNRVNHSEPV SSDGEVRHMV
LRNFNCHRRL IKTFDRENSI VRHVGEFHEG ATLMFGSWEQ MIRNLLSRKT ADFFGITCLS
CVFFYFFVFS SWSGMVSIAS GLLIPQLAIG ALYGRLLGKC IHDIFGGYMG PDDDNAESEW
DFSDPGGLAV LGAASFFAGT SRQPITSAEM TNDINMSLLV MVSVMLAKFV GDRFTHSLVH
SLLEFKCIPI LEPELKIYHN NMRVDLELFP VSLMMSPPIT TLLRSSVFTL ANLLLDTNHG
AFPVVKPIPS DPNKKCVFMG LISRMELTIL LTKTEGFDVN ELNRDDIDRI RITYPEYTST
KLKDCAVTNK ILQMYSTDQR YQQVFVNLYP YINLSYLSVA NTFSLHRAYV VFRDLGLRHL
VVVDEYNEVQ GIVTRKDLLG FAVEEKVKDE ILRIKQYNII RRHKASFRTQ ARVIGAFVSK
YKFVILAFAI KISSSSSLKT VEDISKNKTL GEYSLDKGWP HKNVSDLQVF GSSVTIDNSG
NIVLLHRGFQ GGSKPRNSII HENTVAIIDK NTGKILREWG SNKFLKPHGL FINKDGDLFI
TDTVMHQIFK FDWDNSTKQW NNESSLVIGE PFVAGYGHYR FCSPADIVED PETGNFFVAD
GYCHSRVVKF DKNGKYLLEF GAGSSDLSIP PIPFNVTHAL ALAKRTSTNS THGEIEQPQT
ILLVVDRDSA RIQIFDLNGT FLYEIGASDL GSEHAMILSV ATVTAKNFEF GQAFIIKGHV
PVGEAKMVIV GLQAKNFTII SSHPIMKQKA PTPKLNVTSP KDVKLSMPHD IATKNGKEIY
IVEAINDLTL QRYVWADAKS IAKQHVGKSS SVMTRCPKTL LTVINLIIMT IHTAIIDICS
NHIIVHNFDK VFPPMKFSMA IFQYECRMLA VVLWKSWRIR KHRKWQTLIE ICAPVLLVLL
LVSVKAVMEP DSDVVDNYKP TIFPTQNMKS LTSGLCSIGC SVQSKTAILA YAPNTTFINE
LMTHVGVKIK NNGADLEIHG FKSEQEVEAL ASLLQQNSSG YFGSPSSLTG AVIFVNNPGV
DTNLVYKIRL LTWKFITGKQ FPDIEIAGPG KQYVEYEKTG FLGLQFAIDD AFIQLISTMT
NVTADNFVVE TKPFPYPPYR KLDKSHYTMV LSTLLPSAII IGFVYMISIS IKVIVEERVT
GVKQFLTMLG LSHVGYWFGW FFDLFCVALV SIIFIVLILT TNLTGDGAAL VTSSTSVIWT
FLLLYAVSAL WFCFFIANLL RSASYARGLA AVIWFGTFIV PAILVGTSQR FLATQFLIAI
SPNMCLFWGF NIIATWESRV VGIKWSNMQE YASATHSLNM ASMFSMLIFN SIFYFLLTVI
IRHPLIANRR LKKPYQLLYD ALYDDTKFPE LIRFFKKGCK FIKKSKAVDH PGKDVQFESP
VGALRMKVLD DMGLLHSDNA KSPLTEPVEQ LDSAKECGVK IRNMTKSFNL EMIKGFTCDF
YVNEISCILG DSGSGKTILI DILLGVIKGD EGIAYVNSYD INDYLPDVKR SVGFCPQKNM
LFADLSVMEH LLLFGWLKGK DWSSTMVQAR HVATILKLND ALKTPAKKLT KSTKRLLCCA
IAMMGNPKVI ILDDPVHDMD VDTSKIFWNA LLKYKEGRTI IFSSESIENA ADIADRIAII
NDGKLRCFGT PQYLNSVFGD GYTIKLSIAD SAERLVRMIC SEMEHAHVKN RTLTVGGEDV
TFIVPQAYAF LFPRLFYQLY DNKDALGLIT VQIDSLSVED VFHSVHEMRE FKQQPLTPIL
NVKSSSSTDV SNPAKKSQFS NSSFFIGAKS SGCRLAFIRF WALLVKNYRL SCSQINVLIF
QVLIPVILII SGVNGANRAL RNQDIRRFGQ INIGLDGYRN PITLYGMTHN RLKMLYPLVV
GNYSNPIIPQ NIKISDALLE AGEKNIAKYR HNYLVAANET NSSITAMYST VPFNSPPLSL
NLVTNTILRT VVYPNSKQRI IVENHPLKNS SGADETTSSV ASDSGGAALL KSLCLNAYAL
ALICAMVAVK PMLERVSGSH HLQTMSGVNP FTFWASYLIL DGLYVTVFAG VAVLIFFFAQ
ERYLFTMHGG SVALFLIFLL GGFAVVCFGY FFSQVVNDAA SSFVWLNMLH LLAVLGSHIM
FRTHDGINDG VSELYFWLIT PFPIPFMVHS FYVYGKVVID NSRCELVAHH FSSGICKRKG
LYIHLPAYSC CAQCNSSNCF QPRNYFDASY GYESYTLTRD LVIMGLVALI YFVLVVLMDY
NYFQKLNRYF LSAPSEDFSS ERGEKDPSAA QEAENVRRLI GLGVDVPDDE GLLVDNLCRN
HGNIGEIYSQ VSFDVKKGQC FGLLGLGDAK SLVFKTLTGE ILPDVGDSVI PPYSMLRNRR
QFTTNIGYCP QANCVFSGLT ARETLQLYGS LKGICLSDLM TEVRQWLSAL GLENDSNLLC
GNFTPGMKRR LCVAVALIGN PQVIILDEPS RDIDPSMKKY IWGTLQRLQK DGKVILLASQ
NVHECENLCG KLGLMVHGRL QYVGSAREIK SRFLNGYTVT FKLTKRYSVD DASDLETVSD
IKTSIEACLD DALFRDAFQN TLKYLIPQKT QNWGSIVERL EKIRTQLSAS VAYYSMTEST
LEEVFNAMDD LELESTNNEL PGTRMTPFQR LCLGQCCTDD YS
//