ID A0A226EHK8_FOLCA Unreviewed; 1500 AA.
AC A0A226EHK8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DNA topoisomerase 2-binding protein 1-A {ECO:0000313|EMBL:OXA56106.1};
GN ORFNames=Fcan01_10031 {ECO:0000313|EMBL:OXA56106.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA56106.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA56106.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA56106.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA56106.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA56106.1}.
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DR EMBL; LNIX01000004; OXA56106.1; -; Genomic_DNA.
DR STRING; 158441.A0A226EHK8; -.
DR OMA; NVHCLKT; -.
DR OrthoDB; 449768at2759; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 7.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 2.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR SMART; SM00292; BRCT; 6.
DR SUPFAM; SSF52113; BRCT domain; 5.
DR PROSITE; PS50172; BRCT; 7.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:OXA56106.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287}.
FT DOMAIN 201..267
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 289..378
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 447..537
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 676..758
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 760..862
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1315..1397
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1426..1500
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1500 AA; 166640 MW; C14D14E878DCF04A CRC64;
MMAPPKGGGG GRTTRSTAKR ATVTTTTNNN NNTTTTTTTT NGVRVNQESL RVTRTTVNEA
KKTTRRRRAD EGSVCSMSMY SQSDVGRKED NVIYFVLPEG LTAATCSPTL ARTYVCAQDG
DIESQWITEQ DCIHVVPKPG NMFIVGSFEG PVYERLLGYK KEGQCYLLGP QVLLYLLQQD
DDDKSPELDM GGSTPLFTVG MRNMLITLTG FPKGQKVEQS IKITKMMGIC SGSLTKGVTH
VIAYSLMTEK VLTAYKTNIP VMMPEWIDAV WQDSQNDLVH AVDEKYVKYA CPIFHKLVVC
VSQVFTKLKE AIRNVIEANG GEYSADLTRA KTSILIIPLA TGEKYRFAQE WGVPCATPDW
VEASKSAGHI VPWQDYPVPQ PFKDHPPTST PFNSMVLPKL HVPSNTDDSV LSNINGPTGR
DRDRHVVSQY EYTEDSVKQA VELVKTMSDP FLDGCQIYIC NNQKSEHVRK LVNAGAVRLS
KISDRVTHII LPPNNQLNSS ELQQFKKLDP RPCLMKVQWL IDSAKKGSAT DEELYRINID
SNGAYVMMNQ VDRVAESIII NQSSHYPAEH LVENIRCEVS SSSDNNAGVS SPTANNSSDK
NGDNQQPQIN VNQAKSRSHG SPVNKSLNVQ VGENDFQARY YANEENENIE DENGMNLNQD
EAEHVAEGEM NSLNESEPKL FSGLKFKVEM NNNPNQRIEI ENTLTDNGGK LSSGADYNFL
IVPTLYTAKT GEVHLRTRQW VNDCIDHDAI VDGDAFYFYK PRQPFSGMGS ILVGVVVAIS
QYTNSEKEYI SELVNEMGGK FQDMFARKTV NAVYRTTHLL CAKTDSDKYR AAQKWKTPVV
VAEWVVESFD KKVILDIGPF DPLNRSDSQS TVNYLPQTPV VNSSRVQKAL QTEQKNRKVS
QLQQAAASER QHAPPTSPKE NVNNHVFKTP TSKPRKSTPG DALNEEIPQT DSFIEWKLAN
PTSIEDMDND PEFMEWRAQQ PKRPTPPPAQ ELSPIIGEHY GLSRAQSRGM KALYRELMKT
PSPDIGVIKL RRRQSTPFRD IMARDFAKLA ELIPKARTAE KSQQEDNKSA TSSKRSSTTS
STTDDEEIHV NPASFPKRLR INSSESESEA PGSRKCAKTS SISSPGSTSN YPASSEEDAT
SAAQSGSRKL SSKADDIVDV GAREEQVSST NANGSKNDPS QFNPVEKNKE IPKPIAETQE
HRPTANLQKL ITLLANADDE DEDEEDDDDD EDEEEEEDEN EETDNGKSPS KVHQQVIREE
DQPCAEELDA PPVVWVADSE DFHNDMQQQV GVSPGIVSSQ GRTREIIFKV PPRPTFSLSG
LNDNDKRSVK HKLVRLGGNV SETAMFEPSS FAVIANTLAR SEKVLCAIAS GKPIVTSAYV
DACMEADRFI PITEEFIWKE SDAKTDAVKE LAKSSFCWIR RILKDPTDTP FHGDTFFLEG
KANNKFAAFS RLVQSGGGQI VENKEASTMV LVMDQRSGIV DGRRIENVAY LSDQIINPLR
//
