ID A0A226EHR7_FOLCA Unreviewed; 1114 AA.
AC A0A226EHR7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=CXXC-type zinc finger protein 1 {ECO:0000313|EMBL:OXA56166.1};
GN ORFNames=Fcan01_08798 {ECO:0000313|EMBL:OXA56166.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA56166.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA56166.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA56166.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA56166.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA56166.1}.
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DR EMBL; LNIX01000004; OXA56166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226EHR7; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR022056; CpG-bd_C.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF802; RH55021P; 1.
DR Pfam; PF12269; CpG_bind_C; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 262..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..208
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 263..541
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT DOMAIN 765..1011
FT /note="CpG binding protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12269"
FT REGION 379..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 795..822
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 379..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..456
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 125942 MW; 6620B8A61BDD5B13 CRC64;
MPNRGKVPVL VTYLTLGFSL SDKHFCLGLN RTAGGVTLSA DYDKAFPPLP HPVEVSLKVY
VQTVAPILTS ELEFRVNMRW TLTWVDPRVS LVDPDPDPDD VDPVDPDACT NTSSSTSYVI
APPGFASQIW IPDPYLVNSK FTGIKGFNGK LANLVIFANH TLAYTMILNA TVACDMDFEF
YPLDVQYCPI LVQSFAYDTN RLVFVWRGFD IRPMRLIQFM VVIPEIQPYK RFEYVPLQGN
VSQLVGPFRF ERLISSHLVQ SFIPSTLIVA LSWFGFWLEL DVTAARGYLL MACILSLQIH
LQGLKSEFPP VAYVKAVDVW VFGCISWVFC ALAEFVVVKV VYSVTEVERR GNQVLSLTKI
YLDRNNSLHS KYEFIANNQA TTSAEPSPTT PQLHGMKPDT RPWKKPAETS TPQLSPTTPP
TPYSAFWLWQ ELRDQQQQLP PQPSTPPPPP QLAERPPYPK RRLGSVVLSG RSIATSNLPS
LVEKRVCCGA TLPLIWSRIR DERHDQFGEE FHPRVVLWRE IDNWSKIIFP VTFTIFAVVY
WAVGDRSSCS ERRNFFEGDE ETDTASQVDD KTDTASEVDD EVNVVDLSSE GENDLVSSMD
LLRRKLAMSS LPPSSSSSSF SLAKSMAKME MTPPGKKMAK KSTPTTKTTP SKKPTPTKKL
TPSKKSTPTS SSKKKRHQSE GGSGSGRKIN FDQDISFYLL TCVPISLDHD HPRRPLCVVK
FTNVPVMSES DDDDWDRQCL GLDCIESARP GSKYCSQTCC IELMTHRLHE FMPLKLKAMK
ASKKGVAILR DRDKLRELRG KIEAQREVLS SLEKKRLRLE EYILAVEQLP FEGNPPDSPV
PVEEGSMDCV SCGKHVKVNK LVKHMENCYL KMESKHELVS YKLPFKPSCS QLPIFFDFYD
PRAGTYCRKY ASLCILHEVK RIKKHKNDAA LNPAKIMCGF PSKIEHPSVK DEMCRYNRAK
CNKHFQWERV QRAAIDVERD LQWSKLDTLV QEEGRVRAAM RQRGQGVVGM MLHSTIAHDS
SYVPHQVVEL LAKEDAYFKD IEKKRETEAV KKSDATKTAE ENVVVDASFK DIENKGQTAE
SVKQSDVVNM GEDNVVAHHD EVKCDQEHEI ITID
//
