ID A0A226ELL3_FOLCA Unreviewed; 895 AA.
AC A0A226ELL3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=CSC1-like protein 1 {ECO:0000313|EMBL:OXA57466.1};
GN ORFNames=Fcan01_07820 {ECO:0000313|EMBL:OXA57466.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA57466.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA57466.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA57466.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA57466.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA57466.1}.
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DR EMBL; LNIX01000003; OXA57466.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226ELL3; -.
DR OMA; PKRYYAH; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF153; RE44586P; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..241
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 260..426
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 438..723
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 895 AA; 103547 MW; 553DDB0C08B2FFE6 CRC64;
MEGSNGTNVE KNKLCNIYER YQRSKASGGF SGIRQNIIFS LFGFVIFLLI FSFLRRRLWD
YGVWAVIKRH THNEDLVDSK QFFEPRGRNI RRPGDPVNPS LYKKSKDTFG CETQDRFKLR
WLARQQELDH AILQDRTLFG WIRTTFSLEI EDILHAAGPD CVKYLIFQRH LIGLTFIWTV
ISCAITLPIN YMGSNTGIRN NDPPAVIFLR FSIQNLINKP KYLMVHLSLT VLLILLATIV
LRHFSEYLVC YGDYEDDAFR SVFIQGITRA HNARISEETI RNHLQEVYPN VEIREVLLIY
NFSELFGHYE YFKLFYTMKH LGSFTGKFQK LLDVVATDAI DFYETEEARC KKLLLFEAGS
RLKSRSLGMA VVTFENVEMA FRFINDHSWA MKYFKKIPQS ECSRRLGTDK WKVSLAPHSL
DLLWLNIRSG VTAWYIRFFL LNMLTFFIMC IYTTPVYVLQ GLTTVVPLES LLLAPNKTRN
KTNKLGNEEG AMEKVWTRFM YDTAPVLLLL LFAVTMPSLV TVSDLLAGFW TRSSENRSRM
IKTFTFLIIM VIILPSIGLV TLTKVLAERS HKDLIKTVFR WQCILAPQNG EFFVNYMCTA
TFVGTLSELI RLPEILLFSI YTCCLQSPGE QRSLKLSMLY DFPLGSQYAY TMLYYVTFAV
FSFIFPVITP FGLCYMIVKH FVDKHNIYFV YGPCLTPKQE IHGLASNLLM LGNYLAQFTV
AAYCITQAYF HQLHPKNETT EEKDRFNRGL IFYAILTLVL TLAPYFLHCC CGFCPSLMPV
FYRRTSEPDV TCGPFAPTRR LYYSNRLEIL ADEELKGFYN KAAANRRFAP DVFHDLTFLT
SITSLMNRKC LPAHDSSDSD SEDEFKNADC ARPLPVPSNI IPLNFKSKMI KSPQH
//
