ID A0A226ERQ7_FOLCA Unreviewed; 2231 AA.
AC A0A226ERQ7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Pleckstrin y domain-containing family H member 1 {ECO:0000313|EMBL:OXA59276.1};
GN ORFNames=Fcan01_05919 {ECO:0000313|EMBL:OXA59276.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA59276.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA59276.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA59276.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA59276.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA59276.1}.
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DR EMBL; LNIX01000002; OXA59276.1; -; Genomic_DNA.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17094; FERM_F1_Max1_like; 1.
DR CDD; cd00821; PH; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22903:SF8; MAX-1A; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1248..1343
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1357..1464
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1499..1830
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1841..2163
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 35..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1509..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2179..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 340..388
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 567..608
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 41..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1627..1740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2179..2193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2212..2231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2231 AA; 243548 MW; E8F5CB5FD77CE12E CRC64;
MSGMMEHDSL EDLHRQQDAE FQDILADFAD QQHELEQRMP RTSHSQTSLS LSSVVSNEDT
SESSCAGTLS EVFESLSRFS EHCLASAEAL NSPIYLNTGS FAGTMGSHDE TTPTGPGDNF
EFQFDYDAKC SSTTHGLSRG GESCGGESSA KVFNIDDHRD RERCPVKRSG LFGINEAHHH
RRAEFFRGML ERETTPNRQD IYDNPSTSIA GGQSGPLATN MRDLNFSENQ IQNETTQTSS
VAAACGGSSD RRTGNILLDI GLELEIFTAG LEFGNIIDLP AVPSTSKESI GSAGEASGDS
IVAALNVFRE SGPLVSSRDW QEMSPSSRIL ELELALKRFG QQATRARIML RDKLAELERR
VVEAESRANE AEDKVRVMEQ QLSDSSNAAA AWAMGEEQPD KLCNLQLALT VREKDRVISR
LECQVEEIVI YFVGRNSSPR LKHYVFLQVH HIASILLSNK IRKHMGRPMR REKMGSRMTP
PPPLSSSLMT FFTSRARILR RATIDPAHPL FKTIQPAFLP NLLYVDGIIS PRVWLISLPA
RLEPLLGHRL LRLQESRQVE EKAAKIKEWV SNKLRDLEEQ NECLREQNQK CENQLELLKS
RLTQLSTLEL KSLSKSKDRH STEDSSRGSY EGDRPGSDES PPHDTSEHNG HHVSSSQTAI
SRSAISATAA CIAAIKRRSA AFDSPEERER RRKSNLSNSG STSGGGGVHN GSLRDPDRRD
SRGSRGSRVD SGSVDMETPQ SLSPRSPLDS LEPLDGSLPS MSNGGGVVIG PSSSSSALSE
VQAYTGSGGG GSSQPASAQS LHHHPHNLRH PTSSSSLSSH PSHPLVNGHG VPSGLPHPCL
PSHSSHNNNN NNNNNHVIIS SPSAYPVPPP IPVLHPQPIT ISHSPLPATP NDVMIGGSES
TGSLISDRRA PIVPPRRCRT RSPTPNTSHG TTPGTCSPPT TEEEDATVLR ARLDAECQQL
ARDLQAAVRE LVRPELSLGG ARASNLGGSS SKVNGGSSST RGKAMDEVHD YSEIYTPSAE
TPENCLPLGQ PPPPPIHRFP EWESRIYQVA AGGLKVPSNG KGDTGGVSGG GAGEISCGNG
RILSYHSLGI NFSVPVYTTV KGRASRIRDA PFSGDSSDSS DGEELGSGSG SGPSHPMSSG
ETDISSPGKI SIANSLSPLH RSSSSSKSVR REPSFGESEI SDDYAIPPDA FASETSSLDL
ALSSGCNLTA TGVASIAPGT VSLGPSSGSS NPSGGIVNSV ESSPRKESLE KAGYLTKLGG
TLKTWRKRYF ILKNGTLTYW KTQQEASRRP TGRDILLDDN CRINRGDGAA TFEIVTVKKT
YYLTADSTAG VDEWVKVLQN VVRRNATKLV LSMEDSKPTV QGWLTKVKNG HAKRCWCVLT
GKMFLTFKSP SDTMGTGQVN MRDARVEDVD HVSDDSDKEE SPTNATSDVF TVGIFPSHQS
PIYLHFATKQ EKDSWLYHLT IVSGKGPSVG TQFEQLVHKL MEVDGDPNST LWKNPLLLHS
KESISTPLTS LSSLERSEGE RHQRKERTPH SALQNEAIKL FKSVQLFMSV PLDTSGIDYH
VALAQNALQL CLDYNELQAE LICALVKQTS KQMSYKNVTL HKIKHSRHFL LNATQSLFLC
DSSSNHHGKL HAQQNQSNHQ SSAPSSSSSP PSNPTNSLLT TSSHRANNHH GTIPNTAVGN
NVSKAFNSSL GSNGRSGSLG TSSSSRSSPS KSSKVKASSS KGSSSSVPSS PLLSSHNHSM
HHRALSSEGK SSVRSFVFIQ GWQLLALSVS LFLPKNNKLL WYLKQHLTRN IDTRSECGKY
AAYCQRSIER TLCNGPRLFK PSRMEVLSIF LKNPFHHSLP HSVPVHFLNG SYTVVGFDGS
TTVEEFLHSL CHEIGCREPP LSGFALFEDD PFEKDLEHFL KSDEKVCDVI SQWETALRER
GSGKFETRRA VTLTFKSRIY RRAGVLQESD RERLLLCYQT NRHVVSGKFP LTRELSLELC
ALMAQIDGGD YKPDRGRGSG GSQLIVQILE KYYPIRYRDN LSQEEYKTLC DNLVEKWSFL
KCKSSLDCVR IYLTCTRKWS FFGATLFSVN VRGTHVIEDG SSAWAGICED GIAILDSITL
QQIAKYSYAS VITFGGAVDD HFMIVVDDCG KKRRLLLGGM SKFKVLEMTR LVADYINACC
TFYGGSSANT LGGLTRHNSL KSSRFQGSTT LPPPTPRMER RHLGATPNPS PIPVQRCDSS
NTFHRNQQPH T
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