ID   A0A226ES73_FOLCA        Unreviewed;       648 AA.
AC   A0A226ES73;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=GPR180/TMEM145 transmembrane domain-containing protein {ECO:0000259|Pfam:PF10192};
GN   ORFNames=Fcan01_05804 {ECO:0000313|EMBL:OXA60462.1};
OS   Folsomia candida (Springtail).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC   Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX   NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA60462.1, ECO:0000313|Proteomes:UP000198287};
RN   [1] {ECO:0000313|EMBL:OXA60462.1, ECO:0000313|Proteomes:UP000198287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VU population {ECO:0000313|EMBL:OXA60462.1,
RC   ECO:0000313|Proteomes:UP000198287};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OXA60462.1};
RA   Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT   "The genome of Folsomia candida.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXA60462.1}.
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DR   EMBL; LNIX01000002; OXA60462.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A226ES73; -.
DR   OMA; WFLYELK; -.
DR   OrthoDB; 5473749at2759; -.
DR   Proteomes; UP000198287; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR   InterPro; IPR047831; GPR180/TMEM145.
DR   InterPro; IPR019336; GPR180/TMEM145_TM.
DR   PANTHER; PTHR23252:SF45; GPCRRHOPSN4 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR   Pfam; PF10192; GpcrRhopsn4; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..648
FT                   /note="GPR180/TMEM145 transmembrane domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012985607"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        440..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        479..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        509..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        544..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          308..560
FT                   /note="GPR180/TMEM145 transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF10192"
FT   REGION          145..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  73445 MW;  4501ED486BFC9738 CRC64;
     MLPKTVAHLV IFILLLNGGD TLHLQGTWET GSFFLFLTKF GFQKTELSNK NDTQGYIFGN
     ITSAKDGTWV VTPPPPARRL VKREKGNDAD LLTKKLSSTL KPSTVPIAKP SSIIISSSST
     SSSKNSATLS TKKPENLLNI SQNSILSYSS TSPKPSSTKG ESKRPSGGSS STTTTTTKKT
     VPTTTEPIKV FPATLVVLDR GYFVDFYRNR NNPDRDEACR LMFEHISHVA YDSRCYKDGT
     ERFLKRIPCP RGELCADDKS NTSYVVKDHQ FTYAISDPNQ PKFWYISLVA CYRDPVTCEW
     KHSGNAISVD YDIWLVNGNP YTKNQNPLEY QFSFDRQDTV EIYVVFFICY LVLFPLQVHA
     VLRQRHIVPR LFTGSVVLEL LAVLANVIHV LQFTSNGVGH PSLAAFGDIM DIAARAVFML
     ILLVLAKGWA VTRTELTSKL FIFTIWTLYG VVHILLYVWK ETEVDVIFDI DEYQTWPGWL
     ILVLRNIIMI WFLYELKDTM DHEHQPHKLN FFLHFAAASL VWFIYLPIIA LIALQVTPLW
     RSKLILGITF SFDFLAFAVM SHLLWPTRSQ QYFLLTAKDI SLNDELDVFN HAPHVVNSRR
     SNLRQPGFFS SRGSDSLARN HFNGHENGLS GSANTYDDYK DNTPLIIT
//