ID A0A226F5M3_FOLCA Unreviewed; 1274 AA.
AC A0A226F5M3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Histone-lysine N-methyltransferase eggless {ECO:0000313|EMBL:OXA65093.1};
GN ORFNames=Fcan01_00674 {ECO:0000313|EMBL:OXA65093.1};
OS Folsomia candida (Springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Isotomoidea; Isotomidae; Proisotominae; Folsomia.
OX NCBI_TaxID=158441 {ECO:0000313|EMBL:OXA65093.1, ECO:0000313|Proteomes:UP000198287};
RN [1] {ECO:0000313|EMBL:OXA65093.1, ECO:0000313|Proteomes:UP000198287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VU population {ECO:0000313|EMBL:OXA65093.1,
RC ECO:0000313|Proteomes:UP000198287};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXA65093.1};
RA Faddeeva A., Derks M.F., Anvar Y., Smit S., Van Straalen N., Roelofs D.;
RT "The genome of Folsomia candida.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXA65093.1}.
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DR EMBL; LNIX01000001; OXA65093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226F5M3; -.
DR STRING; 158441.A0A226F5M3; -.
DR OMA; ISACMEC; -.
DR Proteomes; UP000198287; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10517; SET_SETDB1; 1.
DR CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000313|EMBL:OXA65093.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000198287};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OXA65093.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 105..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 972..1045
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1048..1249
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1258..1274
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 144419 MW; BCB5F836BE858389 CRC64;
MTQKVEIDIK NTKSNLAPKN PKSDPAPKTS KSDPAPKNSK SDPTPKNLKS DPAPKNPKSD
QASKNPKPGP PAKNPKSDPS SQTPEPVNEC IATAGICISA CMECFMVTAA CSMFLMILYF
FGILMLCFLA SKGYDVQDYL DPWNMFCKVG LFVVKAIAVL LILAICIEMA SSLYQNSALI
GKMFCDVTTK SWRLVRSTKW GWPNKSLPTC KLVKEKAPID VGKKGVQEIK FDDIVKIENE
KNCDDVAKME MVNECNNANC KSNSDELVIA KEAAILYYRF DMSHKKVHKI CKTCDEDAET
FMQNSVNALK NDENIFAFKT KPEGMEVDVI EIKDDEEDDN NPAEIQRLET DNNEILELST
SVDNLIGEVM TKLDLASQIA KCEETTTMEF ENLEEEYCNL KEQVSLVEGH IAETKKIYNK
VAGYEQPLPV IAVELDLSVT ETLLESMLQN VNDFLNFDDA PPDFQPTPSP ESAESNLNGS
SAEKENSHSD DDDIVEVVPG EGSPQKLTCP LTRPLKDVPR LVPLIGGSVY AQKRTLLHYW
ARATIEEILD VGAGKSEFLV RFVRGDGRLK QLTAKQIAYD IPCPFMLIVG TRVIAKFRED
LKEKPHGPDG HYAGIVAEQP TPRNKFRYLI FFDDGCAQYV GINDILLIHK YSKEVWSDVH
PDSAEFIKNY LRKYPERPMV RLTLGQVIST EWNGKWWVAR VTELDCSLAK MHFENDGRWE
WIYRGCTRFS PLFEKYTRQR QRKIARQSTS ALTYHESYQQ SKDGDDWVPS HGRKKRTEPT
PGTSASALEK QHGDIKRLTR FDYGEFEGTI AKRAIPSDAP LTKEYSPHVC DHSCVYEYDD
SNPEYKKIGP LTLPLHFGFT REIAESPYRS IYYRGPCGLR LHDMEEMYDY LTQTKCQIQI
DHFCFDLAED CLNEFRHSRQ HSFLPDLTYG KEPVPVQLVN AFDHEFPPYV EYLSQRVAGS
GVNFNNDEEF LVGCDCEDDC RDATKCSCWQ MTHSGISFSK FNTPENPITG YEYRRLKNNV
FSGIYECNQR CKCAKTCCNR VAQNGLKVPL QLFKTAAKGW GIRPIFDVPE GAFICIYAGQ
VLTEDAANDD GQQFGDEYLA SLDYIEHIEK LKEDYESEVT DIEADEPVAH PKKKIKTRKE
RPFNTRGKNN AKKTSSGAGN SKNKSGPVIT PPKTKVRRPL REYFGEHDEC YIMDAKTTGN
IGRYFNHSCE PNIFVQNVFV DTHDLRFPWI TFFASKHIRA GSELTWDYAY EVGSIPDKVL
LCQCGSPECR GRLL
//
