ID A0A226MCS0_CALSU Unreviewed; 766 AA.
AC A0A226MCS0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASZ78_003589 {ECO:0000313|EMBL:OXB52978.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB52978.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB52978.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB52978.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB52978.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB52978.1}.
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DR EMBL; MCFN01001628; OXB52978.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226MCS0; -.
DR STRING; 9009.A0A226MCS0; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20816; C1_GMIP-like; 1.
DR CDD; cd04408; RhoGAP_GMIP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF16; GEM-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 282..326
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 340..540
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 200..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 85990 MW; EA6CC90B6B58AB88 CRC64;
MLIKCEGGID AALDYAKLWC KYVKELLSWI EKRLNYETEF AKGIVKIAES GRNAIIHQNE
SLSSLRKSRL QYFQRCEELE KAKQLSAKAE DEYQNAAIVQ ETEALYKMCI NDANFRRQEL
EKVRARIVSH IRKLIYQGDE MLMWVTLRMF KQRQTQSEWI PVGYQHLSEV CKPYRVGEKY
LEFIQALQKK DIPMEHFEFE PHSSRGQSDT ESLSGSCESR SLDSPSSSPG NSSRKLLKAS
STGTMSSSDD FEERDSLQTL ENENGTSQQQ FRNALLSSAA QTHRLRKLRG PTKCRECDAF
MVNGFECEEC YLTCHKKCLE NLLITCGHKK LPNRVSLFGI DFTQVPRDFP EEVPFIVVKC
TSEIEARALG VQGIYRISGS KARVEKLCQA FENGRSLVEL SEHSPHDITG VLKHFLKELS
GPILLHRLYD NLIALAKELQ KNGEEKVDCM SFPSDAIQSM KDLLSKLPGS NYNTLRHLIA
HLVAEKYEEN KMSPNNLGIV FGPTLIRPGS GSDVSMSCLV DSGYQAQIVE FLIQNYERVF
GMEDLPSSLS LGCENPSQEA STEKDEGDQS PNTAQSVILE NHSSNHGSSM DTTSDISPSG
ETIDEFALES VHSSEGGEVN ASIGSEMEDL EEKADSDTEL VLGTQPRGHF SRQPVKYIRA
QPKTRANIPK PSSLPLRAPD SGAQSGPTNS TWMGKEMVEE GTRSRNSSPD VSALRHRGKQ
LKHFEITEET SRIISRFKAE VSPSPEPSSD EKEVKFGPEI IPEKIL
//
