ID A0A226MHR2_CALSU Unreviewed; 1266 AA.
AC A0A226MHR2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASZ78_005767 {ECO:0000313|EMBL:OXB54834.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB54834.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB54834.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB54834.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB54834.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB54834.1}.
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DR EMBL; MCFN01000848; OXB54834.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226MHR2; -.
DR STRING; 9009.A0A226MHR2; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF22; UROMODULIN-LIKE 1; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50024; SEA; 2.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1218..1241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 418..532
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 529..574
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 797..909
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1001..1264
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 281..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1266 AA; 139154 MW; 4235455F96C33850 CRC64;
MRRRRRGEAM WRKVQTTEPG ELISSTFLAK VGCNELFPEC TPECYQPHIA TSFIPLDISS
PFLSFELPHH QNENKQIFHW DLKMVAYQKS YEKNTSCGGW IPWMICPQMY YKTQYHTVEV
PETINFIDCC EGYEQVGLYC CLERKFWYNV TVLVKMDFNE LIRVDSHLLN HSRLLHSMIT
GALQPLNASV HHIQSNHAEI YAGTVASQVL IGLHQPAPLA EVSSSLKKMV KRVYEVIDTD
VKDIDECSYA EFNACPEQNS CVNLEGYYSC SPEHQEAYVS PHQLSTKKDG KKGTAASTPS
SVLDPINTNS CSPSISNSSL LSTTNQSTDA ECYPSAIINH RIFSVTSNSF EMSWYVTSTL
NHTFQVQVFK AKEIVRNLKT EEMNIDVLGL EAGVMYSVEI SYETCGKSIL SHQNVKTEAK
IFGVTMRILN YSFTEDLYDA SSSAYEEFSR LLLTEIGNSF PPNISALYES GKLKVQIESL
KAGSIIVRLR VTVQDPEFPV DASTFAPMLS YLYNGSVLLL DRQNSTVEDW DECASGTDND
CSVFAQCINL VGSYLCRCKT TMDTNPSRPG RNCEGEIVSP LTEKAALEVA SSTQLVPEAS
PTAFAFPAIT VGSEMNTIIY HPAVLPLGES QAPRHHSPTS APPVPWNKTL APHMSRDSSP
TAVTAEQQTT MSPSQQSSLA ESSLCTSQQV ATLTNASIGT GKQEQQTPLP MLSNPSAFGI
SGSHAGFGEP QVHSQDGPIT ALPATGDAGV PTLNTHTQTR RENSSWGENH TTALELTALP
GISLAPKPML SPTVDHTVQK LNGMVRITNV KYSPGFSNAS SEEYQNFTQL FVDEVHRSLP
LDIFQQMDAG LIKVLITDVT NGSTVVSFHL LIAEGVDIYY VITAFRGAIE YSSYFTVDKN
SLSINALPTS QEGTVVDRKP VQNVFLPVTS LETSTSVSSS VSLNFSTTQN KALEDTPFSS
VTLPILTIGS VSVPDVPSQA SPIPLIKPAQ EISIKDAVTV FCEIEKTVLA IQKGFLHQES
ISESSLYLGE PLCNVSISNG THVVLQAGWS ECGTEVETNV TNTVVKTILR NDGSAQGVIH
HLKVASPIHC VFQNNLLTSS GYTAEGIYTI FEDLHGSGHF RTEMQLFIGN SPIPKNFSVS
ASDDVLIEVG IHRADSKLKV VLTDCWATPS NNSVDPLSFA FINNSLPTLQ NSYLYGDSRK
HLQDASDSKR EKDPGVGVGY ITLIVIAVFG FVLAVVSLVI FQCKRKMGRY NFRIKSDNFS
YQVFYE
//
