ID A0A226MLX1_CALSU Unreviewed; 768 AA.
AC A0A226MLX1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=VHS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASZ78_006434 {ECO:0000313|EMBL:OXB56251.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB56251.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB56251.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB56251.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB56251.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB56251.1}.
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DR EMBL; MCFN01000659; OXB56251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226MLX1; -.
DR STRING; 9009.A0A226MLX1; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14240; GAT_GGA3; 1.
DR CDD; cd17008; VHS_GGA3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR044111; GAT_GGA3.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR046996; VHS_GGA3.
DR PANTHER; PTHR45905:SF3; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 16..146
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 171..298
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 639..760
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 378..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..238
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 383..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 83131 MW; BA98E48956744F40 CRC64;
MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW
EAVQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLYS
WTVALPEEYK IKDAYYMLKR QGIVMFDPVI PVDKILIPSP PPRPKNPVFD DEEKSKLLAK
LLKSKNPDDL QEANKLIKSM VKEDEARIQK VTKRMHTLEE VNNNVKLLNE MLVHYSKEDS
SEADRELMKE LCERCETKRR TLFKLASETE DNDSSLGDIL QASDNLSRVI NSYKKTIEGQ
VINGEVDLRV ISGVEVSEEE VGRDSSKAVG SNSTSNLNTL IDLAGLDVSS TPPPAVPPTA
LTPAPTAAPV PAEIPILPPP PQTLSQLRSS SLSQVEAAPT QQSSTANSIS LLDEELLCLG
LNDPAPAAGK ETSENNQWSM FENEQLDLDF FNPKTMTVAC NPAGNPLLHH ASQTTCGTSV
TLPSAFTASQ TAPSMSAPNS IPFVFSAGLA APVGPSKTIP AAPGYLSSSV GSSMPHKMDA
LGQFLEEAKG TATQGMATPS VLPGVTLPAP VTSSPLMAPA GLPVTAPGTS PVPFPNSCTG
VSGGSLFHPA SFQQQGSPMK APEITLANVH VPLESIKPSS ALPVTAYDKN GFRILLHFAK
ECPPGRSDVL VVVVSMLNTA PLPVKNIVLQ AAVPKSMKVK LQPPSGTELS PFNPIQPPAA
ITQIMLLANP AKEKVRLRYR LTFMLGDQLA TEVGEVDQFP PVELWGNL
//
