ID A0A226MSK6_CALSU Unreviewed; 728 AA.
AC A0A226MSK6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
DE Flags: Fragment;
GN ORFNames=ASZ78_003256 {ECO:0000313|EMBL:OXB58228.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB58228.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB58228.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB58228.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB58228.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB58228.1}.
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DR EMBL; MCFN01000486; OXB58228.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226MSK6; -.
DR STRING; 9009.A0A226MSK6; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323}.
FT DOMAIN 405..592
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 290..337
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 575..606
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..26
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OXB58228.1"
SQ SEQUENCE 728 AA; 82416 MW; 4E554B85C8499D2C CRC64;
LDHEPKAVGT NDEDEDEGEQ FDFDSGDEIP EADRQALVPP PPDPGCNTEH QEANVTGTKN
KTLFNFSSKG AENLEKSEKL QASEPSAEDT PRKVNPYSVI NISPMQEKDP SSSPDPSPQD
EPSSPNVTVG YSVPVPCGYA VPSNLPLILP AYSSPVIIRS VSVDEEGMQS ATEECHCNSL
KSEEPQNSEE NQVKREDDAL AKWVADPANT AWMENPDEVI YDDVPRENSD SEPEEMIYDD
VENGDDGGNS SLEYGWSSSE FESYEEQSDS ECKNGIPSSF LRGNHKRHLS HDLTRLKEHY
EKKMKDLMAN TVGAVEIQQL KQKHELKMQK LMRAAREGTK DGLEKTKAAV KKGRSFIRTK
SFISQDHRSS CLEEEELNFF IDVDCMHTEA IMTPMPEGLS QQQVVRRYIL GSVVDSEKNY
VDALKRILEQ YEKPLSEMDP KLLSERKLKM VFYRIKEILQ CHSMFQIALA SRVSEWDSVE
MIGDVFVASF SKSMVLDAYS EYVNNFSTAV GILKKTCATK PAFLDFLKQC QESSPDRITL
YGLMMKPIQR FPQFILLLQD MLKNTNKGHP DRLPLQMALT ELETLAEKLN ERKRDADQRC
EIKQIAKAMN ERYLNKVRNL LSSGNRYLIR TDDMVETVYN DKGEIIKTKE RRLFMLNDVL
MCATVNLRTS YESSGTMTTG QRYLLKWSVP LGQVEVIEYG SSESQGENCR FPPQHSAENV
IVNSKPSK
//
