ID A0A226MU06_CALSU Unreviewed; 606 AA.
AC A0A226MU06;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 22-FEB-2023, entry version 15.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 26 {ECO:0000256|ARBA:ARBA00019686};
DE AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 7 {ECO:0000256|ARBA:ARBA00030125};
DE AltName: Full=Mediator complex subunit 26 {ECO:0000256|ARBA:ARBA00031968};
GN ORFNames=ASZ78_010624 {ECO:0000313|EMBL:OXB58738.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB58738.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB58738.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB58738.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB58738.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC {ECO:0000256|ARBA:ARBA00009681}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB58738.1}.
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DR EMBL; MCFN01000450; OXB58738.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226MU06; -.
DR STRING; 9009.A0A226MU06; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR042376; MED26.
DR InterPro; IPR031416; Med26_C.
DR InterPro; IPR031417; Med26_Mid.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15201; CRSP70; 1.
DR PANTHER; PTHR15201:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26; 1.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF15693; Med26_C; 1.
DR Pfam; PF15694; Med26_M; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000198323}.
FT DOMAIN 11..88
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 92..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 66836 MW; 48FFFABA3EC978E8 CRC64;
MTAAPAPSPQ QIRDRLLQAI DPQSNIHNMV AVLEVISSLE KYPITKEALE ETRLGRLINE
VRKKTSNEEL AKRAKKLLRN WQKLIEPVTP SEAVPRALPN PPGSANGGAH NCKAEAALPA
AAGPKPISEL KSRNDIQKLS SPKAEKLGNR KRKGEHRDGH QGPPAPKVSK VSHEILQNSS
PPPTNGIGGS PENFPSPVDV NLHAGPESSR TELSENDKHS KIPVNAVKPH TSSPGLVKPS
STSSLLKTAV LQQHEKSEES TGSHQPKSPR CSSFSPRNVR HDTFARQHST YSPKDSMPSP
SQRSQFLDTA QVPSPPPSLM QPSTPPMPAK RLELSQQPAP EASQHWQEQQ VAADSQQRHT
APSCKASSHP GESLASHVGF SQDASKMDSD DAASGSDSKK KKRYRPRDYT VNLDGHVTEG
GVKPVRLKER KLTFDPMTGQ IKPLTPKDPL QVEIPALTEQ HRTETEKQEQ KPNLQSPFEQ
TNWKELSRNE IIQSYLNRQS SLLSSSGVQT PGAHYFMSEY LKQEESTRKE ARKTHVLAPN
SKPTDLPGVT REVTGDDLNR IREHNWPGVN GCYDTQGNWY DWTQCISLDP HGDDGRLNIL
PYVCLD
//
