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Database: UniProt
Entry: A0A226MV93_CALSU
LinkDB: A0A226MV93_CALSU
Original site: A0A226MV93_CALSU 
ID   A0A226MV93_CALSU        Unreviewed;       478 AA.
AC   A0A226MV93;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   13-FEB-2019, entry version 8.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   ORFNames=ASZ78_001907 {ECO:0000313|EMBL:OXB58919.1};
OS   Callipepla squamata (Scaled quail).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Odontophoridae; Callipepla.
OX   NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB58919.1, ECO:0000313|Proteomes:UP000198323};
RN   [1] {ECO:0000313|EMBL:OXB58919.1, ECO:0000313|Proteomes:UP000198323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texas {ECO:0000313|EMBL:OXB58919.1,
RC   ECO:0000313|Proteomes:UP000198323};
RC   TISSUE=Leg muscle {ECO:0000313|EMBL:OXB58919.1};
RA   Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA   Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA   Decker J.E., Seabury C.M.;
RT   "Disparate Historic Effective Population Sizes Predicted by Modern
RT   Levels of Genome Diversity for the Scaled Quail (Callipepla squamata)
RT   and the Northern Bobwhite (Colinus virginianus): Inferences from First
RT   and Second Generation Draft Genome Assemblies for Sympatric New World
RT   Quail.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OXB58919.1}.
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DR   EMBL; MCFN01000433; OXB58919.1; -; Genomic_DNA.
DR   Proteomes; UP000198323; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198323};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    478       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013370840.
FT   ACT_SITE    134    134       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    356    356       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     46    339       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    210    226       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    364    375       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    369    426       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    428    437       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   478 AA;  55272 MW;  6DB697DAC71CDD09 CRC64;
     MDLWIRWLAV TVLLTAGDAQ LPKQAQAPLL LHKPFVVVWN APTEQCRQRY KVDLDLSIFD
     IASNTNETLS GSNVTIFYHT HLGYYPYYSE NGDPVNGGVP QNESLIKHLN KAKSDIDYCI
     PMKKFHGLGV IDWENWRPQW DRNWGNKSIY RNKSLEMVRQ RHPQWSEDKI RKVAKEEFEN
     AGKSFMNNTI LLAEHMRPNG LWGYYLYPDC YNYDYKEQWQ TYTGKCPAIE SSRNDLLLWL
     WKESTALYPS IYLDYVLKSS PNALKFVHYR VKEAIRVASI ARKDYVLPVF VYSRPFYAYT
     FHVLTEIDLV NTIGESAALG AAGVVLWGSM QYASSKESCS TVKRYIDGPL GHYVINVTSA
     AKLCSKVLCK KNGRCVRKNS DSSAYLHLPP SDFKIRARRS GRGPRLQVTG ELSLESIEAM
     RQRFMCQCYQ GWTGIFCELP DQSVIEHWVH LVFSRSRKQK IYVFLLGAMQ LFLLYTAY
//
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