ID A0A226MZY3_CALSU Unreviewed; 629 AA.
AC A0A226MZY3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN ORFNames=ASZ78_009397 {ECO:0000313|EMBL:OXB60905.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB60905.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB60905.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB60905.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB60905.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB60905.1}.
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DR EMBL; MCFN01000305; OXB60905.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226MZY3; -.
DR STRING; 9009.A0A226MZY3; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd17480; MFS_SLC40A1_like; 1.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF47; SOLUTE CARRIER FAMILY 40 MEMBER 1; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 63..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 107..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 144..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 171..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 355..381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 387..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 422..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 546..569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT REGION 26..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 67641 MW; 441789EC08EE1A84 CRC64;
MARRAGPAAE RRRCCGQCAA AAAPARLPGA DGAGGERGAA AGPERRGEGA AAGRPQPLSL
SRLGALVGYF TSAKFLLYLG HALSTWGDRM WHFAVSVFLV ELYGNSLLLT AVYGLVVAGS
VLLLGAIIGD WVDKNSRLKV AQTSLVVQNA SVILCGIILM IIFLFKTQLL TLYHGWLLTM
CYILVITIAN IANLASTATA ITIQRDWIVV VAGEDRSKLA DMNATIRRID QLTNILAPMA
VGQIMTFGSP MIGCGFISGW NLMSMCVEYL LLWKVYQKTP TLALKSSKVE ESELKQLNVK
KESDMKPAEG VQLIVEKDVT GFEPRQEKEV GCAARIAEPF ITFRDGWVAY YNQPVFLAGM
GLAFLYMTVL GFDCITTGYA YTQGLSGSVL SLLMGASAIT GIMGTVAFTW LRRKCGLIRT
GLISGVAQFS CLVLCAISVF MPGSPLDLTV SPFADISARL FENEPLPTIA SPGSEPDVAF
ATRMPYLLNG STTPAYSDPE MSPEPVPLIS VSLLFAGVIA ARVGLWSFDL TVTQLLQENV
AESERGIING VQNSMNYLLD LLHFIMVILA PNPEAFGLLV LISVSFVAMG HIMYFRFAQK
SLGKQLFACC TPNPEAVSDS SLPGNTSTV
//
