ID A0A226N152_CALSU Unreviewed; 636 AA.
AC A0A226N152;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Fibulin-1 {ECO:0000256|ARBA:ARBA00021554};
GN ORFNames=ASZ78_002553 {ECO:0000313|EMBL:OXB61316.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB61316.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB61316.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB61316.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB61316.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB61316.1}.
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DR EMBL; MCFN01000280; OXB61316.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226N152; -.
DR STRING; 9009.A0A226N152; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016504; F:peptidase activator activity; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR017048; Fibulin-1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 6.
DR PIRSF; PIRSF036313; Fibulin-1; 2.
DR SMART; SM00104; ANATO; 2.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..636
FT /note="Fibulin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012307977"
FT DOMAIN 61..94
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 96..128
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 309..351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 352..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 394..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 636 AA; 70620 MW; 41EC7E323F9B9E3D CRC64;
MDKLRGARPL RLLLLLALLP ALRGQVTVPD WHICKITTES LYDAILDMKV QCCRSKLEEH
YCSDGIEFAN VHEECDSHIG ENSTCEAEYF KKCCYCCLLG KTAQVQGQSC EPNLKIGYQC
GIVFRACCVK GQEGTDVSIS DDAPKKEQVE ISKEELDQED PYLHDGCRDI NECITGTHSC
GIGQTCVNTL GSFRCQRDTS CGTGYELTDD SRCKDIDECE TGTHNCPPDF ICQNTPGSFR
CRPKLQCMNG FIQDALGNCI DINECLSTNM PCPAGQICIN TDGSYTCQRI SPSCGRGYHL
NEDGTRCVDV DECSSSDQPC GEGHVCINAP GNYRCECKAG YSFDVISRTC IDINECRRYP
GRLCAHKCEN TPGSYYCTCT MGFKLSADGR SCEDLNECES SPCSQECANV YGSYQCYCRR
GFQLSDIDGI SCEDIDECAL PTGGHICSFR CVNIPGSFQC TCPSTGYRLA PNARNCQDID
ECVTETHNCS FNETCFNIQG GFRCLSLECP ENYRKSGDTR CERLPCNENK ECQSLPLRIT
YYHLSFPTNI QVPTDIFRMG PSNAVPGDKI LLSIISGNEE GFFTTKKVNN HSGIVVMQRQ
IKEPRDLLLT IQMQLTRHGT VNTFIAKLFV FVSAQL
//
