ID A0A226N1R0_CALSU Unreviewed; 606 AA.
AC A0A226N1R0;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
GN ORFNames=ASZ78_005912 {ECO:0000313|EMBL:OXB61504.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB61504.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB61504.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB61504.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB61504.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) +
CC N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692,
CC Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461;
CC EC=3.6.1.62; Evidence={ECO:0000256|ARBA:ARBA00024496};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC Evidence={ECO:0000256|ARBA:ARBA00024496};
CC -!- SIMILARITY: Belongs to the DCP1 family.
CC {ECO:0000256|ARBA:ARBA00008778}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB61504.1}.
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DR EMBL; MCFN01000270; OXB61504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226N1R0; -.
DR STRING; 9009.A0A226N1R0; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09804; Dcp1; 1.
DR Gene3D; 6.10.140.2030; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010334; Dcp1.
DR InterPro; IPR031953; mRNA_decap_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16290:SF5; MRNA-DECAPPING ENZYME 1B; 1.
DR PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR Pfam; PF06058; DCP1; 1.
DR Pfam; PF16741; mRNA_decap_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 3: Inferred from homology;
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323}.
FT DOMAIN 565..604
FT /note="mRNA-decapping enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16741"
FT REGION 202..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 66288 MW; 01C251CCE3B4D7FD CRC64;
MAAAVSGAAL LGKGLDISLA ALQQQDPYIS GIVDVASQVA LYTFGHRANE WEKTDVEGTL
FVYTRSASPR HGFTIMNRLS MENRTEPITK DLDFQLQDPF LLYRNARLSI YGIWFYDKEE
CQRIAELMKN LTQQEQFKAQ QGTGAGVSPM IMNSANNKEV DILRMLTKAK DEYTKCKTCS
EPKQISSSSA ICNNPNLIKP IPVKPSENQH QRISQQSKNA DAEPQHLSLT ALFGKQEKTD
VTESLNKQHQ ENLPVRQGVV RSLSYEEPSR HSPCAEKQLC PAIQKLMVRG TDLQPLAEFP
ENRLCENGSI HPVGETFTGL FQPVTSRGIA TSHVVQDAAG TQNLLQKLQS QSGSMTKMDP
SATGSVNSTA SVFSRTPAAV GAPAAQISNM TQPPLVYFNG SLPGQTLESQ TLGKEQSKLP
RQPVSLSGSQ TANSGVISPQ ELLKKLQIVQ QEQLHVSSRP TLAAKFPVVT QNTNTLKPLD
SWIEKTPGTE KQSSLFQVIS PQRIPATVTP TLLMSPMVFT QSAPAASKAN ESGRLAASNQ
EPAASSANLL LPLQTPEPPV ISSSSVTKMQ LQETLLHLIQ NDDNFLNIIY EAYLFSVRKA
AMKKSM
//
