ID A0A226N282_CALSU Unreviewed; 646 AA.
AC A0A226N282;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Muellerian-inhibiting factor {ECO:0000256|ARBA:ARBA00020473};
DE AltName: Full=Anti-Muellerian hormone {ECO:0000256|ARBA:ARBA00030008};
DE AltName: Full=Muellerian-inhibiting substance {ECO:0000256|ARBA:ARBA00031273};
GN ORFNames=ASZ78_006339 {ECO:0000313|EMBL:OXB61651.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB61651.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB61651.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB61651.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB61651.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB61651.1}.
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DR EMBL; MCFN01000264; OXB61651.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226N282; -.
DR STRING; 9009.A0A226N282; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR CDD; cd13757; TGF_beta_AMH; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006799; AMH_N.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR021203; Muellerian-inhibiting_factor.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR15009; MUELLERIAN-INHIBITING FACTOR; 1.
DR PANTHER; PTHR15009:SF4; MUELLERIAN-INHIBITING FACTOR; 1.
DR Pfam; PF04709; AMH_N; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037270; Muellerian-inhibiting_factor; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Gonadal differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..646
FT /note="Muellerian-inhibiting factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012420702"
FT DOMAIN 532..646
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 341..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 70690 MW; 99F4EA563ED11BF9 CRC64;
MKAALGVLLP YVVLLLRSAA LPRKGTPGAE AVLGEKLSEE LGLGAKRENV SRTRPGSAVR
TKMTVASRLL PRSGPAASCT QADGSNLQPW PLGGLEGPVC RLKMGHDEVS PTHLEVVGVL
TRYESGFIKV LRAGWEHHSP ETFGLCPGGG AQTMLRRLQH LQEHLAGPGM GPERFLVLRL
EEVKWEAQAR LWFRLAFQEE LGRVLGELHM ALLLFYPGSP IGQGAEGRQE LLVEGTGLAQ
EQSLCLTGDT QYLLLGASVA AVTRSSEELS FQVSLAIRHR GDGGAPLLPM ETQQLLFGSD
EKCFTRMTPV LLLLARSRPD YDVAAPSSYL SASGVVDVAP YPQLSPPHPG TAELLPPTAP
SLTNTTSPTP GDSGQFLGVL TLFIRRVLSP RSEPPTQPSS QHWLDFQMME TLPHQLLNLS
ETAALERLVQ SEEPSVLLFP QEGSAGLEQH FGDWQPEGTV LQLLMGKLQA VIHELRDIPE
FQANTGLFQH LLSFCYHPPG PAASEQPTGS GKLRALLLLK ALQTVRARWQ ERRKVLRQNR
SARHQAHCRL QELTIDLRDR NFIVMPTVYA ANNCEGPCKL PLSTRVPGYH SHTVLLLGMQ
ERGSPLQRAP CCVPVRYSDQ LIISVSAEGL EVRKFPNMVA EECGCR
//
